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Pyrimidine Nucleosides witha Reactive (β-Chlorovinyl)sulfoneor (β-Keto)sulfone Group at the C5 Position Their Reactionswith Nucleophiles and Electrophiles and Their Polymerase-CatalyzedIncorporation into DNA

机译：嘧啶核苷与反应性（β-氯丁酰基）砜或在C5位的（β-酮）砜基团它们的反应亲核试剂和亲电试剂的聚合反应及其催化掺入DNA

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Transition-metal-catalyzed chlorosulfonylation of 5-ethynylpyrimidine nucleosides provided (E)-5-(β-chlorovinyl)sulfones >A, which undergo nucleophilic substitution with amines or thiols affording >B. The treatment of vinyl sulfones >A with ammonia followed by acid-catalyzed hydrolysis of the intermediary β-sulfonylvinylamines gave 5-(β-keto)sulfones >C. The latter reacts with electrophiles, yielding α-carbon-alkylated or -sulfanylated analogues >D. The 5′-triphosphates of >A and >C were incorporated into double-stranded DNA, using open and one-nucleotide gap substrates, by human or Escherichia coli DNA-polymerase-catalyzed reactions.

机译：过渡金属催化的5-乙炔基嘧啶核苷的氯磺酰化反应提供（E）-5-（β-氯乙烯基）砜> A ，该胺经过胺或硫醇的亲核取代，生成> B 。用氨处理乙烯基砜> A ，然后酸催化水解中间的β-磺酰基乙烯基胺，得到5-（β-酮基）砜> C 。后者与亲电试剂反应，生成α-碳-烷基化或-磺酰化类似物> D 。通过人或大肠杆菌DNA聚合酶催化，使用开放和单核苷酸缺口底物将> A 和> C 的5'-三磷酸酯掺入双链DNA中。反应。

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期刊名称 ACS Omega
作者
SazzadH. Suzol; A. Hasan Howlader; Zhiwei Wen; Yaou Ren; Eduardo E. Laverde; Carol Garcia; Yuan Liu; Stanislaw F. Wnuk; *;
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年(卷),期 2018(3),4
年度 2018
页码 4276–4288
总页数 13
原文格式 PDF
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1. Pyrimidine Nucleosides with a Reactive (β-Chlorovinyl)sulfone or (β-Keto)sulfone Group at the C5 Position, Their Reactions with Nucleophiles and Electrophiles, and Their Polymerase-Catalyzed Incorporation into DNA [J] . SazzadH. Suzol, A. Hasan Howlader, Zhiwei Wen, ACS Omega . 2018,第4期

机译：在C5位置具有反应性（β-氯丁酰基）砜或（β-酮）砜基的嘧啶核苷，它们与亲核试剂和亲电试剂的反应以及它们的聚合酶催化并入DNA
2. Effect of imino group of a linker arm at the C5 position of a pyrimidine nucleoside on the thermal stabilities of DNA/DNA and DNA/RNA duplexes. [J] . Ozaki H, Mine M, Shinozuka K, Nucleosides, nucleotides and nucleic acids . 2004,第1a2期

机译：嘧啶核苷C5位的连接臂亚氨基对DNA / DNA和DNA / RNA双链体热稳定性的影响。
3. Uracil Nucleosides with Reactive Group at C5 Position: 5-(1-Halo-2-sulfonylvinyl)uridine Analogues [J] . Liang Yong, Suzol Sazzad H., Wen Zhiwei, Organic letters . 2016,第6期

机译：在C5位置具有反应基团的尿嘧啶核苷：5-（1-卤代-2-磺酰基乙烯基）尿苷类似物
4. Novel nucleoside analogues with bases modified with (β-halo)vinyl sulfone or β-keto sulfone as probes to study RNA/DNA-Proteins interactions [O] . Sk Md Sazzad Hossain Suzol -1

机译：具有用（β-卤素）乙烯基砜或β-酮砜作为研究RNA / DNA-蛋白相互作用的碱基（β-卤素）乙烯基砜或β-酮砜的基础核苷类似物

Pyrimidine Nucleosides witha Reactive (β-Chlorovinyl)sulfoneor (β-Keto)sulfone Group at the C5 Position Their Reactionswith Nucleophiles and Electrophiles and Their Polymerase-CatalyzedIncorporation into DNA

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