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Sensitivity of novel silicate and borate-based glass structures on in vitro bioactivity and degradation behaviour

机译：新型硅酸盐和硼酸盐基玻璃结构对体外生物活性和降解行为的敏感性

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Three novel glass compositions, identified as NCL2 (SiO2-based), NCL4 (B2O3-based) and NCL7 (SiO2-based), along with apatite-wollastonite (AW) were processed to form sintered dense pellets, and subsequently evaluated for their in vitro bioactive potential, resulting physico-chemical properties and degradation rate. Microstructural analysis showed the carbonated hydroxyapatite (HCA) precipitate morphology following SBF testing to be composition-dependent. AW and the NCL7 formulation exhibited greater HCA precursor formation than the NCL2 and NCL4-derived pellets. Moreover, the NCL4 borate-based samples showed the highest biodegradation rate; with silicate-derived structures displaying the lowest weight loss after SBF immersion. The results of this study suggested that glass composition has significant influence on apatite-forming ability and also degradation rate, indicating the possibility to customise the properties of this class of materials towards the bone repair and regeneration process.
机译：将三种新的玻璃成分（分别为NCL2（基于SiO2的基体），NCL4（基于B2O3的基体）和NCL7（基于SiO2的基体）以及磷灰石-硅灰石（AW）进行处理，形成烧结的致密颗粒，然后对其烧结进行评估。体外生物活性潜能，由此产生的理化性质和降解速率。显微组织分析表明，经过SBF测试后，碳酸羟基磷灰石（HCA）沉淀形态是成分依赖性的。与源自NCL2和NCL4的颗粒相比，AW和NCL7制剂显示出更大的HCA前体形成。此外，基于NCL4硼酸盐的样品显示出最高的生物降解率。硅酸盐衍生的结构在SBF浸没后显示出最低的重量损失。这项研究的结果表明，玻璃成分对磷灰石的形成能力以及降解速率都有重要影响，这表明有可能针对骨骼修复和再生过程定制此类材料的性能。

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