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Is there a role for diet monotherapy in adult epilepsy?

机译:饮食单一疗法在成人癫痫病中有作用吗?

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摘要

Ten adults were treated with ketogenic diet monotherapy for epilepsy. Four patients were naïve to antiseizure drugs (ASDs), and six previously tried and stopped ASDs. Of four treatment-naïve participants, two (50%) were free from disabling seizures on Modified Atkins Diet (MAD) monotherapy for > 1 year. Two (50%) stopped. Four of six patients (67%) who had previously tried ASDs became seizure-free on diet monotherapy, and two experienced > 50% seizure reduction. Side effects included amenorrhea, weight loss, osteoporosis, and hyperlipidemia. Diet monotherapy may be feasible, well-tolerated, and effective for adults with epilepsy who refuse pharmacotherapy and those for whom lifelong diet therapy is recommended.
机译:十名成年人接受了生酮饮食单一疗法治疗癫痫。 4名患者未使用抗癫痫药物(ASD),另有6名先前尝试过并停止使用的ASD。在四名未接受过治疗的参与者中,有两名(50%)在使用改良的阿特金斯饮食(MAD)单一疗法治疗超过1年的时间内无癫痫发作。两个(50%)停了下来。先前尝试过ASD的六名患者中有四名(67%)在饮食单一疗法中无癫痫发作,而两名患者癫痫发作减少了> 50%。副作用包括闭经,体重减轻,骨质疏松和高脂血症。对于拒绝药物治疗的癫痫成人和建议终生饮食治疗的成年人,饮食单一疗法可能是可行的,耐受性良好且有效的。

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