• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Frontiers in Pharmacology >Shexiang Baoxin Pill Corrects Metabolic Disorders in a Rat Model of Metabolic Syndrome by Targeting Mitochondria
【2h】

Shexiang Baoxin Pill Corrects Metabolic Disorders in a Rat Model of Metabolic Syndrome by Targeting Mitochondria

机译：射香保心丸通过靶向线粒体纠正大鼠代谢综合征模型中的代谢紊乱

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Metabolic syndrome (MS) is a global epidemic that has great socioeconomic and public health implications. This study reports observed effects of the Shexiang Baoxin Pill (SBP) in a rat model of MS and explores its underlying mechanisms of action.Methods: A diet-induced rat model of MS was established according to accepted methods, and the rats were randomly divided into two groups: a control group (0.9% NaCl, 100 mg/kg•d) and a SBP-treated group (SBP, 100 mg/kg•d). Systolic blood pressures, fasting blood glucose (FBS) levels, triglyceride (TG) levels, high-density lipoprotein cholesterol (HDL-C) levels, body weights, and abdominal perimeters were dynamically monitored and analyzed. Serum leptin, adiponectin, TNF-α, IL-6, and IL-10 levels were measured by ELISA. Leptin, adiponectin, TNF-α, IL-6, and IL-10 expression in adipose tissue, as well as AMP-activated protein kinase (AMPK) and peroxisome proliferator-activated receptor gamma coactivator 1-α (PGC-1α) expression in heart, liver, skeletal muscle, and adipose tissue was measured by western blot. Expression of the mitochondrial protein UCP2, Cytochrome b and ATPase was observed by immunofluorescent staining.Results: SBP significantly decreased serum TG, TC, LDL-C levels and increased HDL-C levels. SBP also optimized the leptin/adiponectin ratio by decreasing leptin expression and increasing adiponectin expression in adipose tissue. SBP antagonized inflammatory reactions by promoting IL-10 expression in adipose tissue while inhibiting TNF-α and IL-6 expression. SBP improved lipid metabolism by up-regulating the expression of AMPK and PGC-1α. Furthermore, SBP decreased the severity of MS and its complications by adjusting the expression of several mitochondrial proteins, including UCP2, Cytochrome b and ATPase.Conclusion: SBP exhibits prominent therapeutic effects in the setting of MS. Possible mechanisms of action may be related to its anti-inflammatory and anti-oxidative characteristics, as well as its effects on improving lipid metabolism and protecting mitochondrial function.
机译：背景：代谢综合症（MS）是一种全球流行病，对社会经济和公共健康都有重大影响。这项研究报告了观察性射囊保心丸（SBP）在MS大鼠模型中的作用，并探讨了其潜在的作用机制。方法：根据公认的方法建立了饮食诱导的MS大鼠模型，将大鼠随机分为两组：对照组（0.9％NaCl，100 mg / kg • d）和SBP治疗组（SBP，100 mg / kg • d）。动态监测和分析收缩压，空腹血糖（FBS）水平，甘油三酸酯（TG）水平，高密度脂蛋白胆固醇（HDL-C）水平，体重和腹围。通过ELISA测量血清瘦素，脂联素，TNF-α，IL-6和IL-10水平。脂肪组织中的瘦素，脂联素，TNF-α，IL-6和IL-10的表达，以及AMP激活的蛋白激酶（AMPK）和过氧化物酶体增殖物激活的受体γ共激活因子1-α（PGC-1α）的表达通过蛋白质印迹法测量心脏，肝脏，骨骼肌和脂肪组织。免疫荧光染色观察到线粒体蛋白UCP2，细胞色素b和ATP酶的表达。结果：SBP显着降低了血清TG，TC，LDL-C水平和HDL-C水平。 SBP还通过降低脂肪组织中的瘦素表达和增加脂联素表达来优化瘦素/脂联素的比例。 SBP通过促进脂肪组织中IL-10的表达同时抑制TNF-α和IL-6的表达来拮抗炎症反应。 SBP通过上调AMPK和PGC-1α的表达来改善脂质代谢。此外，SBP还可以通过调节UCP2，细胞色素b和ATPase等多种线粒体蛋白的表达来降低MS的严重程度及其并发症。结论： SBP在MS的治疗中具有突出的治疗作用。可能的作用机制可能与其抗炎和抗氧化特性以及对改善脂质代谢和保护线粒体功能的作用有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号