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首页> 美国卫生研究院文献>Gut >Magnesium hydrogen breath test using end expiratory sampling to assess achlorhydria in pernicious anaemia patients.
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Magnesium hydrogen breath test using end expiratory sampling to assess achlorhydria in pernicious anaemia patients.

机译：使用呼气末采样进行氢气氢呼气试验以评估恶性贫血患者的胃酸缺乏症。

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A modified magnesium hydrogen breath test, using end expiratory breath sampling, is described to investigate achlorhydria. The efficacy of this test in the diagnostic investigation of pernicious anaemia was compared with that of serum pepsinogen I. Twenty one patients with pernicious anaemia--that is, patients with achlorhydria--and 22 with healed duodenal ulcer and normal chlorhydria were studied. Magnesium hydrogen breath test, serum pepsinogen I, serum gastrin, and standard gastric acid secretory tests were performed in all subjects. The mean (SEM) hydrogen peak value was lower in patients with pernicious anaemia than in the duodenal ulcer group (21.7 (1.9) v 71.3 (5.2) ppm; p = 0.00005). The hydrogen peak value had a 95.2% sensitivity and a 100% specificity to detect pentagastrin resistant achlorhydria. Mean serum pepsinogen I concentrations were also significantly lower in patients with pernicious anaemia than in the duodenal ulcer group (10.7 (2.7) v 123.6 (11.8) micrograms/l p = 0.00005). Sensitivity and specificity to detect pernicious anaemia were both 100% for pepsinogen I. It is concluded that this modified magnesium hydrogen breath test is a simple, noninvasive, cost effective, and accurate method to assess achlorhydria and may be useful in the diagnostic investigation of patients with suspected pernicious anaemia.
机译：一种改良的氢氢气呼气试验，使用呼气末呼气取样，用于研究胃酸缺乏症。将该试验在恶性贫血的诊断研究中的功效与血清胃蛋白酶原I的功效进行了比较。研究了21例恶性贫血的患者（即，胃酸缺乏症患者）和22例十二指肠溃疡愈合和正常的胃酸过少的患者。在所有受试者中进行了镁氢呼气试验，血清胃蛋白酶原I，血清胃泌素和标准胃酸分泌试验。恶性贫血患者的平均（SEM）氢峰值低于十二指肠溃疡组（21.7（1.9）vs 71.3（5.2）ppm; p = 0.00005）。氢峰值具有95.2％的灵敏度和100％的特异性，可检测抗五肽胃泌素的胃酸缺乏症。恶性贫血患者的平均血清胃蛋白酶原I浓度也明显低于十二指肠溃疡组（10.7（2.7）vs 123.6（11.8）微克/ l p = 0.00005）。胃蛋白酶原I检测恶性贫血的敏感性和特异性均为100％。结论是，这种改良的镁氢呼气试验是一种简单，无创，经济高效且准确的评估胃酸缺乏症的方法，可能对患者的诊断研究有用疑似恶性贫血。

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