• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Medicine >Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion
【2h】

Yiqi Huayu recipe relieves nerve root constriction induced radicular neuralgia by down-regulating TRPV4 expression in dorsal root ganglion

机译：益气化瘀方下调TRPV4在背根神经节中的表达缓解神经根收缩引起的神经痛

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of this study was to observe the effects of Yiqi Huayu recipe on TRPV4 expression in radicular neuralgia model induced by chronic constriction to the rat lumber nerve root. Healthy male SD rats were divided into 3 groups for radicular neuralgia (RN) model construction: the sham operation group, model groups (day 3, 7, 14 and 28), and medication groups (day 3, 7, 14 and 28). Von-Frey hairs test was performed to detect the 50% with drawal threshold (50% TPW) for rats of each group. The expression of TRPV4 in dorsal root ganglion was detected at both mRNA and protein level. Rats from all model groups displayed hyperalgesia with significantly reduced 50% TPW values compared with sham-operation group (P<0.01); Yiqi Huayu recipe medication groups showed higher 50% TPW than model group since 7 days post medication (P<0.01); the medication groups showed decreased TRPV4 expression than that of model groups (P<0.01). In conclusion, Yiqi Huayu recipe alleviates nerve root constriction induced radicular neuralgia by repressing TRPV4 expression in dorsal root ganglion.
机译：本研究的目的是观察益气化瘀方对慢性收缩大鼠木材神经根所致神经根痛模型中TRPV4表达的影响。将健康的雄性SD大鼠分为3组，以建立神经神经痛（RN）模型：假手术组，模型组（第3、7、14和28天）和药物治疗组（第3、7、14和28天）。进行Von-Frey毛发测试，以检测每组大鼠的50％具有抽气阈值（50％TPW）。在mRNA和蛋白质水平均检测到TRPV4在背根神经节中的表达。与假手术组相比，所有模型组的大鼠均表现出痛觉过敏，TPW值明显降低（P <0.01）。自服药7天以来，益气化瘀方药组TPW高于模型组50％（P <0.01）。药物治疗组TRPV4表达较模型组降低（P <0.01）。结论：益气化瘀方通过抑制背根神经节中TRPV4的表达，减轻神经根收缩引起的神经根神经痛。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号