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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Preclinical animal study and human clinical trial data of co-electrospun poly(l-lactide-co-caprolactone) and fibrinogen mesh for anterior pelvic floor reconstruction
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Preclinical animal study and human clinical trial data of co-electrospun poly(l-lactide-co-caprolactone) and fibrinogen mesh for anterior pelvic floor reconstruction

机译：共电纺丝聚乳酸（l-丙交酯-己内酯）和纤维蛋白原网用于骨盆前路重建的临床前动物研究和人类临床试验数据

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摘要

Synthetic and biological materials are commonly used for pelvic floor reconstruction. In this study, host tissue response and biomechanical properties of mesh fabricated from co-electrospun poly(l-lactide-co-caprolactone) (PLCL) and fibrinogen (Fg) were compared with those of polypropylene mesh (PPM) in a canine abdominal defect model. Macroscopic, microscopic, histological, and biomechanical evaluations were performed over a 24-week period. The results showed that PLCL/Fg mesh had similar host tissue responses but better initial vascularization and graft site tissue organization than PPM. The efficacy of the PLCL/Fg mesh was further examined in human pelvic floor reconstruction. Operation time, intraoperative blood loss, and pelvic organ prolapse quantification during 6-month follow-up were compared for patients receiving PLCL/Fg mesh versus PPM. According to the pelvic organ prolapse quantification scores, the anterior vaginal wall 3 cm proximal to the hymen point (Aa point), most distal edge of the cervix or vaginal cuff scar point (C point), and posterior fornix point (D point) showed significant improvement (P<0.01) at 1, 3, and 6 months for both groups compared with preoperatively. At 6 months, improvements at the Aa point in the PLCL/Fg group were significantly more (P<0.005) than the PPM group, indicating that, while both materials improve the patient symptoms, PLCL/Fg mesh resulted in more obvious improvement.
机译：合成和生物材料通常用于骨盆底重建。在这项研究中，比较了在犬腹部缺损中，由共电纺丝聚乳酸（l-丙交酯-己内酯）（PLCL）和纤维蛋白原（Fg）与聚丙烯网（PPM）制成的网的宿主组织反应和生物力学性能。模型。在24周内进行了宏观，微观，组织学和生物力学评估。结果表明，PLCL / Fg网孔具有相似的宿主组织反应，但与PPM相比，其初始血管形成和移植部位组织更好。 PLCL / Fg筛网的功效在人体骨盆底重建中得到了进一步检验。比较接受PLCL / Fg滤网和PPM的患者在6个月的随访期间的手术时间，术中失血量和盆腔器官脱垂量化。根据盆腔器官脱垂量化评分，显示出处女膜点近3 cm处的前阴道壁（Aa点），子宫颈的最远端边缘或阴道袖口疤痕点（C点）和后穹ni点（D点）。与术前相比，两组在1、3和6个月时均有显着改善（P <0.01）。在6个月时，PLCL / Fg组Aa点的改善显着高于PPM组（P <0.005），这表明，尽管这两种材料均可改善患者症状，但PLCL / Fg滤网的改善更为明显。

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