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首页> 美国卫生研究院文献>IOS Press Open Library >Positive and Negative Experiences of Social Support and Risk of Dementia in Later Life: An Investigation Using the English Longitudinal Study of Ageing
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Positive and Negative Experiences of Social Support and Risk of Dementia in Later Life: An Investigation Using the English Longitudinal Study of Ageing

机译：社会支持和晚年痴呆症风险的正面和负面经验：使用英语纵向纵向研究调查

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>Background: Having a network of close relationships may reduce the risk of developing dementia. However, social exchange theory suggests that social interaction entails both rewards and costs. The effects of quality of close social relationships in later life on the risk of developing dementia are not well understood.>Objective: To investigate the effects of positive and negative experiences of social support within key relationships (spouse or partner, children, other immediate family, and friends) on the risk of developing dementia in later life.>Methods: We analyzed 10-year follow up data (2003/4 to 2012/13) in a cohort of 10,055 dementia free (at baseline) core participants aged 50 years and over from the English Longitudinal Study of Ageing (ELSA). Incidence of dementia was identified from participant or informant reported physician diagnosed dementia or overall score of informant-completed IQCODE questionnaire. Effects of positive and negative experiences of social support measured at baseline on risk of developing dementia were investigated using proportional hazards regression accommodating interval censoring of time-to-dementia.>Results: There were 340 (3.4%) incident dementia cases during the follow-up. Positive social support from children significantly reduced the risk of dementia (hazard ratio, HR = 0.83, p = 0.042, 95% CI: 0.69 to 0.99). Negative support from other immediate family (HR = 1.26, p = 0.011, CI: 1.05 to 1.50); combined negative scores from spouse and children (HR = 1.23, p = 0.046, CI: 1.004 to 1.51); spouse, children, and other family (HR = 1.27, p = 0.021, CI = 1.04 to 1.56); other family & friends (HR = 1.25, p = 0.033, CI: 1.02 to 1.55); and the overall negative scores (HR = 1.31, p = 0.019, CI: 1.05 to 1.64) all were significantly associated with increased risk of dementia.>Conclusion: Positive social support from children is associated with reduced risk of developing dementia whereas experiences of negative social support from children and other immediate family increase the risk. Further research is needed to better understand the causal mechanisms that drive these associations.
机译：>背景：拥有密切的人际关系网络可以减少患痴呆症的风险。但是，社会交换理论表明，社会互动既需要回报，也需要付出代价。 >目的：研究关键关系（配偶或伴侣）中社会支持的正面和负面经历的影响，儿童，其他直系亲戚和朋友）在以后的生活中患痴呆症的风险。>方法：我们在一个队列研究中分析了10年随访数据（2003/4至2012/13）。来自英语纵向年龄研究（ELSA）的10,055名年龄在50岁及以上的无痴呆症（基线）核心参与者。从参与者或知情者报告的医生诊断为痴呆症或知情者填写的IQCODE问卷的总体评分中识别出痴呆症的发病率。使用比例风险回归适应痴呆时间间隔检查，研究了基线时社会支持的正负经历对痴呆发展风险的影响。>结果：有340（3.4％）事件发生随访期间有痴呆病例。儿童的积极社会支持显着降低了痴呆症的风险（危险比，HR = 0.83，p = 0.042，95％CI：0.69至0.99）。其他直系亲属的负面支持（HR = 1.26，p = 0.011，CI：1.05至1.50）；配偶和子女的综合负面得分（HR = 1.23，p = 0.046，CI：1.004至1.51）;配偶，子女和其他家庭（HR = 1.27，p = 0.021，CI = 1.04至1.56）;其他家人和朋友（HR = 1.25，p = 0.033，CI：1.02至1.55）;总体阴性评分（HR = 1.31，p = 0.019，CI：1.05至1.64）均与痴呆症的患病风险显着相关。>结论：儿童积极的社会支持与患痴呆症的风险降低相关患痴呆症，而儿童和其他直系亲属的负面社会支持则增加了患病风险。需要进一步研究以更好地理解驱动这些关联的因果机制。

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