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首页> 美国卫生研究院文献>Journal of Anatomy and Physiology >Restricted expression of the gap junctional protein connexin 43 in the arterial system of the rat
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Restricted expression of the gap junctional protein connexin 43 in the arterial system of the rat

机译：间隙连接蛋白连接蛋白43在大鼠动脉系统中的限制性表达

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Connexin 43 (Cx43) has been reported to be expressed in vascular smooth muscle cells and endothelial cells. Evidence for possible variations in Cx43 distribution within different parts of the vascular system is limited. We have therefore investigated the expression of Cx43 in the endothelia and media of 11 vessels of different size and function in the rat, using immunofluorescence and confocal laser scanning microscopy. The results showed that punctate Cx43 staining was abundant in the endothelia and media of all of the 5 elastic arteries examined. In the media, the amount of Cx43 staining decreased as the size of the elastic arteries became smaller. In the 6 muscular arteries examined, 2 different patterns of Cx43 staining were observed. In the first type, Cx43 expression was high in the endothelium but virtually absent from the media. Mesenteric resistance, hepatic and tail arteries were examples. In the second type, Cx43 staining was absent from both the media and the endothelia. The coronary, basilar, and middle cerebral arteries showed this appearance. The results suggest that expression of Cx43 is largely restricted to elastic arteries in the arterial system of the rat. The lack of immunodetectable Cx43 from the media of all muscular arteries examined, and from the endothelia of some of these arteries, raises the possibility of significant differences in the form of expression of Cx43 in these vessels or the presence of other connexins.
机译：据报道，连接蛋白43（Cx43）在血管平滑肌细胞和内皮细胞中表达。血管系统不同部位Cx43分布可能发生变化的证据有限。因此，我们使用免疫荧光和共聚焦激光扫描显微镜研究了Cx43在大鼠血管内皮和11种不同大小和功能的血管中的表达。结果表明，在检查的所有5条弹性动脉的内皮和介质中，点状Cx43染色均丰富。在培养基中，随着弹性动脉的大小变小，Cx43染色量减少。在检查的6条肌肉动脉中，观察到2种不同的Cx43染色模式。在第一种类型中，Cx43在内皮中高表达，但实际上在培养基中不存在。肠系膜阻力，肝动脉和尾动脉为例。在第二种类型中，培养基和内皮细胞都没有Cx43染色。冠状动脉，基底动脉和大脑中动脉显示出这种外观。结果表明，Cx43的表达主要限于大鼠动脉系统中的弹性动脉。所检查的所有肌肉动脉和某些血管的内皮细胞均缺乏免疫可检测的Cx43，这增加了这些血管中Cx43表达形式或其他连接蛋白存在显着差异的可能性。

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