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首页> 美国卫生研究院文献>Journal of Anatomy and Physiology >Nociceptive and sympathetic innervations in the abaxial part of the cranial horn of the equine medial meniscus: an immunohistochemical approach
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Nociceptive and sympathetic innervations in the abaxial part of the cranial horn of the equine medial meniscus: an immunohistochemical approach

机译：马内侧半月板颅角背面的伤害性和交感神经支配：一种免疫组织化学方法

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摘要

In athletic horses, diseases leading to lameness are of great importance due to the loss of performance and the resultant economic concerns. Although stifle lesions are frequent in the hindlimb, due to the large size and complexity of the joint, and although meniscal tears have been identified as the most common soft tissue injuries in this joint, little is known about the mechanism that causes the painful sensation and thus the lameness. The aim of our study was to highlight any peripheral fibres involved in meniscal nociception in five macroscopically sound cranial horns of the equine medial meniscus, which has been one of the most common sites reported for equine meniscal injuries. Immunohistochemical stainings were performed using antibodies against Substance P in order to identify nociceptive fibres; against tyrosine hydroxylase for detecting postganglionic sympathetic fibres; and against glial fibrillary acidic proteins in order to identify Schwann cells. Our work highlights for the first time the presence of nociceptive and sympathetic fibres in equine menisci. They were found in the abaxial part of the cranial horn of the equine medial meniscus. This study suggests that when the abaxial part is injured, the meniscus itself could be the source of pain. These findings could provide a better understanding of the clinical presentation of horses with meniscal injury and contribute towards improving therapeutic strategies to alleviate pain in cases of equine meniscal injury.
机译：在运动马匹中，由于性能下降和随之而来的经济问题，导致la行的疾病非常重要。尽管由于关节的大小和复杂性，窒息性病变在后肢中很常见，并且尽管半月板撕裂已被确定为该关节中最常见的软组织损伤，但对引起疼痛感和疼痛的机制却知之甚少。因此，the子。我们研究的目的是在马内侧半月板的五个宏观健全的颅角中突出显示参与半月板伤害感受的任何外周纤维，这是报告的马半月板损伤最常见的部位之一。使用抗P物质的抗体进行免疫组织化学染色，以鉴定伤害性纤维。抗酪氨酸羟化酶检测节后交感神经纤维；并针对神经胶质纤维酸性蛋白，以鉴定雪旺细胞。我们的工作首次强调了马半月板中存在伤害性和交感纤维。它们被发现在马内侧半月板的颅角的背面。这项研究表明，当背面部分受伤时，弯月面本身可能是疼痛的根源。这些发现可以提供对半月板损伤马的临床表现的更好理解，并有助于改善治疗策略以减轻马半月板损伤的疼痛。

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