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首页> 美国卫生研究院文献>The Journal of Automatic Chemistry >Structural and Quantitative Analysis of Three C-Glycosylflavones by Variable Temperature Proton Quantitative Nuclear Magnetic Resonance
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Structural and Quantitative Analysis of Three C-Glycosylflavones by Variable Temperature Proton Quantitative Nuclear Magnetic Resonance

机译：可变温度质子定量核磁共振对三种C-糖基黄酮的结构和定量分析

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摘要

Quantitative nuclear magnetic resonance is a powerful tool in drug analysis because of its speed, precision, and efficiency. In present study, the application of variable temperature proton quantitative nuclear magnetic resonance (VT-1H-qNMR) for the calibration of three C-glycosylflavones including orientin, isoorientin, and schaftoside as reference substances was reported. Since there was conformational equilibrium due to the restricted rotation around the C(sp3)-C(sp2) bond in C-glycosylflavones, the conformational behaviors were investigated by VT-NMR and verified by molecular mechanics (MM) calculation. The VT-1H-qNMR method was validated including the linearity, limit of quantification, precision, and stability. The results were consistent with those obtained from mass balance approach. VT-1H-qNMR can be deployed as an effective tool in analyzing C-glycosylflavones.
机译：定量核磁共振由于其速度，精确度和效率而成为药物分析的有力工具。在本研究中，报道了可变温度质子定量核磁共振（VT- 1 H-qNMR）在校准作为参考物质的Orientin，isoorientin和schaftoside三种C-糖基黄酮中的应用。由于在C-糖基黄酮中围绕C（sp 3 ）-C（sp 2 ）键的旋转受到限制，因此存在构象平衡，因此通过VT研究了构象行为-NMR并通过分子力学（MM）计算验证。验证了VT- 1 H-qNMR方法的线性，定量限，精密度和稳定性。结果与通过质量平衡法获得的结果一致。 VT- 1 H-qNMR可以作为分析C-糖基黄酮的有效工具。

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