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首页> 美国卫生研究院文献>The Journal of Biophysical and Biochemical Cytology >Aggresomes Resemble Sites Specialized for Virus Assembly
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Aggresomes Resemble Sites Specialized for Virus Assembly

机译：Aggresomes类似于专门用于病毒汇编的站点

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摘要

The large cytoplasmic DNA viruses such as poxviruses, iridoviruses, and African swine fever virus (ASFV) assemble in discrete perinuclear foci called viral factories. Factories exclude host proteins, suggesting that they are novel subcellular structures induced by viruses. Novel perinuclear structures, called aggresomes are also formed by cells in response to misfolded protein (Johnston, J.A., C.L. Ward, and R.R. Kopito. 1998. J. Cell Biol. 143:1883–1898; García-Mata, R., Z. Bebök, E.J. Sorscher, and E.S. Sztul. 1999. J. Cell Biol. 146:1239–1254). In this study, we have investigated whether aggresomes and viral factories are related structures. Aggresomes were compared with viral factories produced by ASFV. Aggresomes and viral factories were located close to the microtubule organizing center and required an intact microtubular network for assembly. Both structures caused rearrangement of intermediate filaments and the collapse of vimentin into characteristic cages, and both recruited mitochondria and cellular chaperones. Given that ASFV factories resemble aggresomes, it is possible that a cellular response originally designed to reduce the toxicity of misfolded proteins is exploited by cytoplasmic DNA viruses to concentrate structural proteins at virus assembly sites.
机译：大型细胞质DNA病毒（例如痘病毒，虹膜病毒和非洲猪瘟病毒（ASFV））在离散的核周病灶中聚集，称为病毒工厂。工厂排除了宿主蛋白，表明它们是病毒诱导的新型亚细胞结构。细胞也会响应错误折叠的蛋白质而形成新的核周结构，称为聚集体（Johnston，JA，CL Ward和RR Kopito。1998。J.Cell Biol。143：1883-1898；García-Mata，R.，Z。 Bebök，EJ Sorscher和ES Sztul。1999. J. Cell Biol。146：1239-1254）。在这项研究中，我们调查了聚集体和病毒工厂是否是相关结构。将Aggresomes与ASFV生产的病毒工厂进行了比较。聚集体和病毒工厂位于微管组织中心附近，需要完整的微管网络进行组装。这两种结构都引起中间丝的重排和波形蛋白塌陷成特征性的笼子，并募集了线粒体和细胞伴侣。鉴于ASFV工厂类似于聚集体，细胞质DNA病毒可能利用最初旨在减少错折叠蛋白毒性的细胞反应来在病毒装配位点集中结构蛋白。

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