The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling Endothelial Cell Migration and Tumor Angiogenesis

机译：α1β1和α2β1整合素为血管内皮生长因子信号转导内皮细胞迁移和肿瘤血管生成提供关键支持

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

Angiogenesis is a complex process, involving functional cooperativity between cytokines and endothelial cell (EC) surface integrins. In this study, we investigated the mechanisms through which the α1β1 and α2β1 integrins support angiogenesis driven by vascular endothelial growth factor (VEGF). Dermal microvascular EC attachment through either α1β1 or α2β1 supported robust VEGF activation of the Erk1/Erk2 (p44/42) mitogen-activated protein kinase signal transduction pathway that drives EC proliferation. Haptotactic EC migration toward collagen I was dependent on α1β1 and α2β1 as was VEGF-stimulated chemotaxis of ECs in a uniform collagen matrix. Consistent with the functions of α1β1 and α2β1 in supporting signal transduction and EC migration, antibody antagonism of either integrin resulted in potent inhibition of VEGF-driven angiogenesis in mouse skin. Moreover, combined antagonism of α₁β₁ and α₂β₁ substantially reduced tumor growth and angiogenesis of human squamous cell carcinoma xenografts. Collectively, these studies identify critical collaborative functions for the α₁β₁ and α₂β₁ integrins in supporting VEGF signal transduction, EC migration, and tumor angiogenesis.

机译：血管生成是一个复杂的过程，涉及细胞因子与内皮细胞（EC）表面整合素之间的功能性协同作用。在这项研究中，我们研究了α1β1和α2β1整合素支持由血管内皮生长因子（VEGF）驱动的血管生成的机制。通过α1β1或α2β1引起的皮肤微血管EC附着支持Erk1 / Erk2（p44 / 42）丝裂原激活的蛋白激酶信号转导途径的强劲VEGF激活，从而驱动EC增殖。趋向EC向胶原蛋白I的迁移依赖于α1β1和α2β1，在均匀胶原蛋白基质中VEGF刺激EC的趋化性也一样。与α1β1和α2β1在支持信号转导和EC迁移中的功能一致，任一种整联蛋白的抗体拮抗作用均能有效抑制小鼠皮肤中VEGF驱动的血管生成。此外，α_{1 β_{1 和α_{2 β_{1 的联合拮抗作用大大降低了人类的肿瘤生长和血管生成鳞状细胞癌异种移植。这些研究共同确定了α_{1 β_{1 和α_{2 β_{1 整合素在支持中的关键协作功能VEGF信号转导，EC迁移和肿瘤血管生成。}}}}}}}}

著录项

期刊名称 Journal of the Boston Society of Medical Sciences
作者
Donald R. Senger; Carole A. Perruzzi; Michael Streit; Victor E. Koteliansky; Antonin R. de Fougerolles; Michael Detmar;
展开▼
作者单位

展开▼
年(卷),期 2002(160),1
年度 2002
页码 195–204
总页数 10
原文格式 PDF
正文语种
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Cross-talk between endothelial and tumor cells via basic fibroblast growth factor and vascular endothelial growth factor signaling promotes lung cancer growth and angiogenesis [J] . Du Heng, Shi Hui, Chen Dali, Oncology letters . 2015,第3期

机译：通过碱性成纤维细胞生长因子和血管内皮生长因子信号传导的内皮细胞与肿瘤细胞之间的串扰促进了肺癌的生长和血管生成
2. Vascular endothelial-cadherin stimulates syndecan-1 -coupled insulin-like growth factor-1 receptor and cross-talk between alpha V beta3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenesis [J] . Alan C. Rapraeger, Brian J. Ell, Madhuchhanda Roy, The FEBS journal . 2013,第10期

机译：血管生成过程中内皮细胞的扩散开始时，血管内皮钙黏附素刺激syndecan-1偶联的胰岛素样生长因子1受体和αV beta3整合素与血管内皮生长因子受体2之间的串扰。
3. Nuclear receptor COUP-TFII controls pancreatic islet tumor angiogenesis by regulating vascular endothelial growth factor/vascular endothelial growth factor receptor-2 signaling [J] . QinJ., ChenX., Yu-LeeL.-Y., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2010,第21期

机译：核受体COUP-TFII通过调节血管内皮生长因子/血管内皮生长因子受体-2信号传导来控制胰岛胰岛肿瘤血管生成
4. Accelerated blood clearance of targeted ultrasound contrast reduced molecular imaging signal intensity: Secreted Frizzled Related Protein-2 signal remained significantly higher than signal from either Vascular Endothelial Growth Factor Receptor-2 or alphaVbeta3 integrin [C] . James Tsuruta, Rachel White, Nancy Klauber-DeMore, IEEE International Ultrasonics Symposium . 2019

机译：靶向超声对比的加速血液清除降低分子成像信号强度：分泌的毛毡细胞纤维蛋白-2信号仍然明显高于来自血管内皮生长因子受体-2或alphavbeta3整合素的信号显着高于信号
5. Vascular Endothelial Growth Factor (VEGF) Presentation Modulates Endothelial Cell Signaling and Vascular Branching in engineered matrices in vitro and in vivo. [D] . Gojgini, Shiva. 2014

机译：血管内皮生长因子（VEGF）的表达可在体内和体外调节工程基质中的内皮细胞信号传导和血管分支。
6. Cross-talk between endothelial and tumor cells via basic fibroblast growth factor and vascular endothelial growth factor signaling promotes lung cancer growth and angiogenesis [O] . HENG DU, HUI SHI, DALI CHEN, -1

机译：通过碱性成纤维细胞生长因子和血管内皮生长因子信号传导的内皮细胞与肿瘤细胞之间的串扰促进了肺癌的生长和血管生成
7. The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis [O] . Donald R. Senger, Carole A. Perruzzi, Michael Streit, 2002

机译：α1β1和α2β1整合素为血管内皮生长因子信号，内皮细胞迁移和肿瘤血管生成提供关键支持

The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling Endothelial Cell Migration and Tumor Angiogenesis

摘要

著录项

相似文献

相关主题

期刊订阅