• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >Immunohistologic cellular phenotypes of lymphoproliferative disorders. Comprehensive evaluation of 564 cases including 257 non-Hodgkins lymphomas classified by the International Working Formulation.
【2h】

Immunohistologic cellular phenotypes of lymphoproliferative disorders. Comprehensive evaluation of 564 cases including 257 non-Hodgkins lymphomas classified by the International Working Formulation.

机译：淋巴增生性疾病的免疫组织细胞表型。综合评估根据国际工作配方分类的564例病例包括257例非霍奇金淋巴瘤。

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The plethora of classifications for non-Hodgkin's lymphomas (NHLs) and controversy regarding the merits of the individual classification schemes has led to the articulation of an International Working Formulation for NHL classification by a working group sponsored by the National Cancer Institute. This classification is based on both architectural and cytologic features and has been shown to have clinical relevance, but it is not an immunologic approach. With the use of frozen sections and both polyclonal and monoclonal antibodies, a comprehensive immunohistologic study was made of 564 biopsy specimens 1) for determination of the utility of the principle of monoclonality in differentiating benign from malignant lymphoproliferative disorders, 2) for definition of the immunohistochemical phenotypes of histologically benign and malignant cellular proliferations, and 3) for evaluation of the immunologic phenotype of 257 non-Hodgkin's lymphomas classified by the International Working Formulation. Two hundred seven "reactive benign" lymphoproliferations demonstrated polyclonal immunostaining. Monoclonal kappa light chain immunostaining was demonstrated in 3 of 4 cases classified as atypical hyperplasia, two of which had coexistent NHL or subsequently developed overt NHL. Frozen tissue sections were found to be essential for demonstration of immunoglobulin and glycoprotein membrane antigens. The results of immunohistochemical studies were readily integrated with the International Formulation. Although diffuse mixed and small lymphocytic lymphomas were immunologically heterogeneous (both T- and B-cell), follicular lymphomas were invariably of B-cell type, and immunoblastic lymphomas originating from homogeneous T- and B-cell populations were identified.
机译：非霍奇金淋巴瘤（NHLs）的过多分类以及有关个别分类方案优劣的争议，导致了由美国国家癌症研究所（National Cancer Institute）赞助的工作组阐明了一项针对NHL分类的国际工作方案。该分类基于结构特征和细胞学特征，并且已显示具有临床相关性，但这不是免疫学方法。利用冷冻切片以及多克隆抗体和单克隆抗体，对564个活检标本进行了全面的免疫组织学研究：1）确定单克隆原理在区分良性和恶性淋巴增生性疾病中的效用； 2）定义免疫组化组织学良性和恶性细胞增殖的表型，以及3）用于评估根据国际工作制剂分类的257种非霍奇金淋巴瘤的免疫表型。 ２７７个“反应性良性”淋巴组织增生显示多克隆免疫染色。在被分类为非典型增生的4例病例中有3例进行了单克隆kappa轻链免疫染色，其中2例共存NHL或随后发展为明显的NHL。发现冷冻的组织切片对于证明免疫球蛋白和糖蛋白膜抗原至关重要。免疫组化研究的结果很容易与国际制剂结合。尽管弥漫性混合型和小型淋巴细胞性淋巴瘤在免疫学上是异质性的（T细胞和B细胞），但滤泡性淋巴瘤始终是B细胞类型，并且可以鉴定出均质T细胞和B细胞群体的免疫母细胞性淋巴瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号