Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

机译：小肠固有层树突状细胞通过视黄酸促进Foxp3 T reg细胞的新生

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To maintain immune homeostasis, the intestinal immune system has evolved redundant regulatory strategies. In this regard, the gut is home to a large number of regulatory T (T reg) cells, including the Foxp3⁺ T reg cell. Therefore, we hypothesized that the gut environment preferentially supports extrathymic T reg cell development. We show that peripheral conversion of CD4⁺ T cells to T reg cells occurs primarily in gut-associated lymphoid tissue (GALT) after oral exposure to antigen and in a lymphopenic environment. Dendritic cells (DCs) purified from the lamina propria (Lp; LpDCs) of the small intestine were found to promote a high level of T reg cell conversion relative to lymphoid organ–derived DCs. This enhanced conversion by LpDCs was dependent on TGF-β and retinoic acid (RA), which is a vitamin A metabolite highly expressed in GALT. Together, these data demonstrate that the intestinal immune system has evolved a self-contained strategy to promote T reg cell neoconversion.

机译：为了维持免疫稳态，肠道免疫系统已经进化出多余的调节策略。在这方面，肠道是大量调节性T（T reg）细胞的所在地，包括Foxp3 ^{+ T reg细胞。因此，我们假设肠道环境优先支持胸腺外T reg细胞的发育。我们表明，CD4 ^{+ T细胞向T reg细胞的外周转化主要发生在口服抗原后和在淋巴细胞减少的环境中，与肠道相关的淋巴样组织（GALT）中。发现从小肠固有层（Lp; LpDCs）纯化的树突状细胞（DC）相对于淋巴器官来源的DC促进高水平的T reg细胞转化。 LpDC的这种增强的转化取决于TGF-β和视黄酸（RA），后者是在GALT中高度表达的维生素A代谢产物。总之，这些数据表明肠道免疫系统已发展出一种自成一体的策略来促进T reg细胞新转化。}}

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期刊名称 The Journal of Experimental Medicine
作者
Cheng-Ming Sun; Jason A. Hall; Rebecca B. Blank; Nicolas Bouladoux; Mohamed Oukka; J. Rodrigo Mora; Yasmine Belkaid;
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作者单位

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年(卷),期 2016(204),8
年度 2016
页码 1775–1785
总页数 11
原文格式 PDF
正文语种
中图分类免疫学;医学史;
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专利

1. Cutting Edge: Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase in Lung CD103+ but Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T Cells and Promote Airway Tolerance [J] . Anupriya Khare, Nandini Krishnamoorthy, Timothy B. Oriss, The journal of immunology . 2013,第1期

机译：前沿：吸入的抗原上调肺CD103 +中的视黄醛脱氢酶，但不是浆细胞样树突状细胞诱导CD4 + T细胞中的Foxp3 De Novo并提高气道耐受性
2. Cutting edge: Inhaled antigen upregulates retinaldehyde dehydrogenase in lung CD103+ but not plasmacytoid dendritic cells to induce Foxp3 de novo in CD4+ T cells and promote airway tolerance [J] . KhareA., KrishnamoorthyN., OrissT.B., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第1期

机译：前沿：吸入的抗原上调肺CD103 +中的视黄醛脱氢酶，但不上浆细胞样树突状细胞，从而诱导CD4 + T细胞中的Foxp3 de novo并增强气道耐受性
3. Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells. [J] . Guilliams M, Crozat K, Henri Blood: The Journal of the American Society of Hematology . 2010,第10期

机译：引流皮肤的淋巴结包含真皮来源的CD103（-）树突状细胞，可组成性地产生视黄酸并诱导Foxp3（+）调节性T细胞。
4. Overexpression of SREBP-1 Promotes De Novo Fatty Acid Synthesis and Triglyceride Accumulation in Goat Mammary Epithelial Cells [C] . Huifen Xu, Jun Luo, Yingting Hou, 4th international symposium on dairy cow nutrition and milk quality proceedings . 2015

机译：SREBP-1的过表达促进山羊乳腺上皮细胞中从头脂肪酸合成和甘油三酸酯积累。
5. The role of T cell-associated polarizing transcription factors in dendritic cell priming of T cells towards immunity or tolerance; role of T-bet or Foxp3 ectopic expression in dendritic cells. [D] . Lipscomb, Michael Wheeler. 2009

机译：T细胞相关的极化转录因子在T细胞树突细胞引发免疫或耐受中的作用； T-bet或Foxp3异位表达在树突状细胞中的作用
6. Inhaled Antigen Upregulates Retinaldehyde Dehydrogenase In Lung CD103+ But Not Plasmacytoid Dendritic Cells To Induce Foxp3 De Novo in CD4+ T cells and Promote Airway Tolerance [O] . Anupriya Khare, Nandini Krishnamoorthy, Timothy B. Oriss, -1

机译：吸入的抗原上调肺CD103 +中的视黄醛脱氢酶但不是浆细胞样树突状细胞诱导CD4 + T细胞中的Foxp3 De Novo并提高气道耐受性
7. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid [O] . Sun, Cheng-Ming, Hall, Jason A., Blank, Rebecca B., 2007

机译：小肠固有层树突状细胞通过视黄酸促进Foxp3 T reg细胞的新生
8. Repopulation of the Gut Lamina Propria with IgA Containing Cells by Lymphoid Cells Isolated from the Gut Lamina Propria (Homing of Gut IgA Cells) [R] . Tseng, J. 1984

机译：通过从肠道固有层分离的淋巴细胞（肠道Iga细胞的归巢）重建含有Iga的肠道的肠道固有层

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

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