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首页> 美国卫生研究院文献>Journal of Experimental Neuroscience >Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution
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Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution

机译：为何向妈妈施加压力：作为潜在问题的同种疗法和作为解决方案的烟酰胺核糖

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The remodeling of female mammalian physiology to support the development of a fertilized egg into an externally breathing individual and then to provide all the nutrition to this individual while remodeling back to nearly her pregestational state is without parallel in male mammalian physiological transitions. While it is common parlance to refer to postpartum depression as a not infrequent stress in women, the postpartum physiological changes after every birth constitute profound metabolic stresses that are understudied and have important nutritional, behavioral, and neurodevelopmental implications for the maternal and neonatal health of every mammalian species. We discovered that the postpartum liver of a lactating female mouse has a depressed nicotinamide adenine dinucleotide (NAD) metabolome linked to circulation of higher levels of NAD metabolites in support of a >20-fold increase in NAD coenzymes in the mammary. Furthermore, by supporting a new mother’s apparent higher demand for NAD precursors, we increased circulation of prolactin, superinduced mammary biosynthetic programs, increased her time of arched-back nursing, enhanced mammary production of brain-derived neurotrophic factor, promoted postgestational weight loss, advanced the neurobehavioral development of her offspring, and allowed them to mature as stronger and more resilient adults with advantages in hippocampal neurogenesis and body composition. These results show that a new mother’s capacity for biosynthesis and functionally important nurturing is apparently limited by NAD. Here, we discuss homeorhetic flow of resources from a new mother to her offspring in the context of NAD metabolism and suggest avenues for future investigation.
机译：雌性哺乳动物生理学的重塑支持受精卵发展为具有外部呼吸能力的个体，然后向该个体提供所有营养，同时重塑到几乎她的孕前状态，这在雄性哺乳动物的生理过渡中是无与伦比的。虽然通常将产后抑郁症称为女性的不常见压力，但每次分娩后的产后生理变化构成了深刻的代谢压力，人们对其进行了深入研究，并对每个人的产妇和新生儿健康具有重要的营养，行为和神经发育影响哺乳动物。我们发现，哺乳期雌性小鼠的产后肝中烟酰胺腺嘌呤二核苷酸（NAD）代谢组与低水平的NAD代谢产物循环相关，从而支持乳腺中NAD辅酶增加> 20倍。此外，通过支持新母亲对NAD前体的明显更高需求，我们增加了催乳素的循环，超诱导的乳腺生物合成程序，增加了她的拱背护理时间，增强了脑源性神经营养因子的乳腺生成，促进了孕后体重减轻，晚期她的后代的神经行为发育，并使其成长为具有海马神经发生和身体成分优势的更强壮，更有韧性的成年人。这些结果表明，NAD显然限制了新母亲的生物合成能力和功能上重要的营养。在这里，我们讨论了在NAD代谢的背景下从新妈妈到后代的同种异体资源流动，并提出了进一步研究的途径。

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