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An Overlooked Brain Region in the Aetiology of Anorexia Nervosa: The Importance of Behaviourally Driven Neuroimaging Analysis

机译:神经性厌食症病因中被忽视的大脑区域:行为驱动神经影像分析的重要性

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摘要

The neurobiological contributions to anorexia nervosa (AN) remain poorly understood, hindering the development of effective neurobiological treatments such as medications and brain stimulation. A large number of studies have been undertaken utilising neuroimaging techniques, such as magnetic resonance imaging (MRI), to gain a better understanding of the brain mechanisms involved in the illness. However, the analyses undertaken by many studies have utilised a whole-brain analytical approach as much of this research has been exploratory in nature. This is, however, problematic as small brain regions that differ between groups may not have the statistical power to produce statistically significant results. This is highlighted in a recent study undertaken by our group utilising diffusion-weighted imaging. In this research, we identified widespread white matter microstructural differences in individuals with AN, but only showed differences in a small brain region (the superior colliculus) when a region-of-interest approach that was driven by behavioural findings was utilised. The importance of hypothesis-driven neuroimaging analyses is discussed in this article.
机译:对神经性厌食症(AN)的神经生物学贡献仍然知之甚少,阻碍了有效的神经生物学治疗方法的发展,例如药物和脑刺激。利用神经成像技术(例如磁共振成像(MRI))进行了大量研究,以更好地了解与疾病相关的脑机制。但是,由于许多研究本质上是探索性的,因此许多研究进行的分析都采用了全脑分析方法。但是,这是有问题的,因为各组之间不同的小脑区域可能没有产生统计上显着结果的统计能力。我们小组利用扩散加权成像技术进行的一项最新研究突显了这一点。在这项研究中,我们发现了患有AN的个体中广泛存在的白质微观结构差异,但仅在使用行为发现驱动的感兴趣区域方法时,才显示出大脑小区域(上丘)的差异。本文讨论了假设驱动的神经影像分析的重要性。

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