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首页> 美国卫生研究院文献>Journal of Neural Transplantation >Hippocampal Proliferation Is Increased in Presymptomatic Parkinsons Disease and due to Microglia
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Hippocampal Proliferation Is Increased in Presymptomatic Parkinsons Disease and due to Microglia

机译：有症状的帕金森氏病和小胶质细胞引起的海马增殖增加

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摘要

Besides dopamine-deficiency related motor symptoms, nonmotor symptoms, including cognitive changes occur in Parkinson's disease (PD) patients, that may relate to accumulation of α-synuclein in the hippocampus (HC). This brain region also contains stem cells that can proliferate. This is a well-regulated process that can, for example, be altered by neurodegenerative conditions. In contrast to proliferation in the substantia nigra and subventricular zone, little is known about the HC in PD. In addition, glial cells contribute to neurodegenerative processes and may proliferate in response to PD pathology. In the present study, we questioned whether microglial cells proliferate in the HC of established PD patients versus control subjects or incidental Lewy body disease (iLBD) cases as a prodromal state of PD. To this end, proliferation was assessed using the immunocytochemical marker minichromosome maintenance protein 2 (MCM2). Colocalization with Iba1 was performed to determine microglial proliferation. MCM2-positive cells were present in the HC of controls and were significantly increased in the presymptomatic iLBD cases, but not in established PD patients. Microglia represented the majority of the proliferating cells in the HC. This suggests an early microglial response to developing PD pathology in the HC and further indicates that neuroinflammatory processes play an important role in the development of PD pathology.
机译：除了多巴胺缺乏相关的运动症状外，帕金森氏病（PD）患者还会出现非运动症状，包括认知变化，这可能与海马（HC）中α-突触核蛋白的积累有关。这个大脑区域还包含可以增殖的干细胞。这是一个调节良好的过程，例如可以通过神经退行性疾病改变。与黑质和脑室下区域的增殖相反，对PD中的HC知之甚少。此外，神经胶质细胞有助于神经退行性过程，并可能响应PD病理而增殖。在本研究中，我们质疑成年PD患者与对照组或偶发性路易体病（iLBD）案例相比，PD患者的HC中小胶质细胞是否增殖。为此，使用免疫细胞化学标记微染色体维持蛋白2（MCM2）评估增殖。与Iba1进行共定位以确定小胶质细胞的增殖。 MCM2阳性细胞存在于对照组的HC中，在有症状的iLBD病例中明显增加，但在既定的PD患者中则没有。小胶质细胞代表了HC中大多数的增殖细胞。这表明HC对HC中PD病理发展有早期的小胶质细胞反应，并进一步表明神经炎症过程在PD病理发展中起重要作用。

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