首页> 美国卫生研究院文献>The Journal of Neurology and Psychopathology >Muscle biopsy findings conduction velocity and refractory period of single motor nerve fibres in schizophrenia.
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Muscle biopsy findings conduction velocity and refractory period of single motor nerve fibres in schizophrenia.

机译:精神分裂症的肌肉活检结果单发运动神经纤维的传导速度和不应期。

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摘要

Eight untreated and eight neuroleptic treated male schizophrenic patients were studied. Light and electron microscopical analysis of muscle biopsies from the anterior tibial muscle showed a spectrum of pathological changes without significant quantitative or qualitative differences between the two groups. The changes included atrophic fibres, central nuclei, "moth-eaten fibres", "ring fibres", fibre splitting and subsarcolemmal and intermyofibrillar glycogen droplets. Electrophysiological investigation of single motor unit properties showed impaired peripheral impulse propagation in both patient groups while the conduction velocity and the refractory period of single motor nerve fibres were within the same range as in healthy subjects. In conclusion there are neuromuscular abnormalities in schizophrenic patients which cannot be attributed to medication or drug abuse.
机译:研究了八名未经治疗的和八名接受精神抑制药治疗的男性精神分裂症患者。胫骨前肌肌肉活检的光镜和电镜观察显示,两组病理变化无明显定量或定性差异。变化包括萎缩性纤维,中枢核,“蛀虫纤维”,“环状纤维”,纤维分裂以及肌膜下和肌原纤维间糖原液滴。对单个运动单位特性的电生理研究表明,两个患者组的外周脉冲传播均受到损害,而单个运动神经纤维的传导速度和不应期与健康受试者处于同一范围内。总之,精神分裂症患者存在神经肌肉异常,不能归因于药物治疗或药物滥用。

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