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首页> 美国卫生研究院文献>The Journal of Neurology and Psychopathology >Botulinum toxin treatment of cranial-cervical dystonia spasmodic dysphonia other focal dystonias and hemifacial spasm.
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Botulinum toxin treatment of cranial-cervical dystonia spasmodic dysphonia other focal dystonias and hemifacial spasm.

机译：肉毒杆菌毒素治疗颅颈肌张力障碍痉挛性肌张力障碍其他局灶性肌张力障碍和半面肌痉挛。

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In the past five years, 477 patients with various focal dystonias and hemifacial spasm received 3,806 injections of botulinum A toxin for relief of involuntary spasms. A definite improvement with a global rating greater than or equal to 2 on a 0-4 scale, was obtained in all 13 patients with spasmodic dysphonia, 94% of 70 patients with blepharospasm, 92% of 13 patients with hemifacial spasm, 90% of 195 patients with cervical dystonia, 77% of 22 patients with hand dystonia, 73% of 45 patients with oromandibular dystonia, and in 90% of 21 patients with other focal dystonia who had adequate follow up. While the average duration of maximum improvement lasted about 11 weeks after an injection (range seven weeks in patients with hand dystonia to 15 weeks in patients with hemifacial spasm), some patients benefited for over a year. Only 16% of the 941 treatment visits with follow up were not successful. Except for transient focal weakness, there were very few complications or systemic effects attributed to the injections. This study supports the conclusion that botulinum toxin injections are a safe and effective therapy for patients with focal dystonia and hemifacial spasm.
机译：在过去的五年中，有477例患有各种局灶性肌张力障碍和面肌痉挛的患者接受了3,806次注射的肉毒杆菌A毒素注射，以缓解非自愿性痉挛。在所有13例痉挛性肌张力障碍患者，70例眼睑痉挛患者中94％，13例半面肌痉挛患者中92％，90％的患者中获得了明显的改善，总体评分在0-4上大于或等于2。 195例宫颈肌张力障碍患者，22例手部肌张力障碍患者中的​​77％，45例颌下肌张力障碍患者以及在21例接受了充分随访的其他局灶性肌张力障碍患者中的​​90％。注射后最大改善的平均持续时间约为11周（手张力障碍患者为7周，面肌痉挛患者为15周），但有些患者受益超过一年。 941例随访治疗中只有16％失败。除了短暂的局灶性肌无力外，注射引起的并发症或全身影响很少。这项研究支持以下结论：肉毒杆菌毒素注射对局灶性肌张力障碍和面肌痉挛患者是一种安全有效的疗法。

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