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首页> 美国卫生研究院文献>Journal of Virology >Pseudotype virions formed between mouse hepatitis virus and lactate dehydrogenase-elevating virus (LDV) mediate LDV replication in cells resistant to infection by LDV virions.
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Pseudotype virions formed between mouse hepatitis virus and lactate dehydrogenase-elevating virus (LDV) mediate LDV replication in cells resistant to infection by LDV virions.

机译：在小鼠肝炎病毒和乳酸脱氢酶升高病毒（LDV）之间形成的假型病毒体介导LDV在抵抗LDV病毒体感染的细胞中复制。

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摘要

Infection of cultures of peritoneal macrophages with both lactate dehydrogenase-elevating virus (LDV) and mouse hepatitis virus (MHV) resulted in the formation of pseudotype virions containing LDV RNA which productively infected cells that are resistant to infection by intact LDV virions but not to infection by MHV. These cells were mouse L-2 and 3T3-17Cl-1 cells as well as residual peritoneal macrophages from persistently LDV-infected mice. Productive LDV infection of these cells via pseudotype virions was inhibited by antibodies to the MHV spike protein or to the MHV receptor, indicating that LDV RNA entered the cells via particles containing the MHV envelope. Simultaneous exposure of L-2 cells to both LDV and MHV resulted in infection by MHV but not by LDV. The results indicate that an internal block to LDV replication is not the cause of the LDV nonpermissiveness of many cell types, including the majority of the macrophages in an adult mouse. Instead, LDV permissiveness is restricted to a subpopulation of mouse macrophages because only these cells possess a surface component that acts as an LDV receptor.
机译：腹膜巨噬细胞培养物同时被乳酸脱氢酶升高病毒（LDV）和小鼠肝炎病毒（MHV）感染，导致形成了含有LDV RNA的假型病毒体，该病毒体生产性感染了能抵抗完整LDV病毒体感染但不感染的细胞。由MHV。这些细胞是小鼠L-2和3T3-17Cl-1细胞，以及来自持续被LDV感染的小鼠的残留腹膜巨噬细胞。这些细胞通过伪型病毒体的生产性LDV感染被MHV穗蛋白或MHV受体的抗体抑制，表明LDV RNA通过含有MHV包膜的颗粒进入细胞。 L-2细胞同时接触LDV和MHV会导致MHV感染，而不是LDV感染。结果表明，LDV复制的内部障碍不是导致许多细胞类型（包括成年小鼠中大多数巨噬细胞）LDV不允许的原因。相反，LDV的容许性仅限于小鼠巨噬细胞的亚群，因为只有这些细胞具有充当LDV受体的表面成分。

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