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Blood mercury lead cadmium manganese and selenium levels in pregnant women and their determinants: the Japan Environment and Children’s Study (JECS)

机译：孕妇的血液中汞铅镉锰和硒的含量及其决定因素：日本环境与儿童研究（JECS）

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The Japan Environment and Children’s Study (JECS) is a birth-cohort study of 100,000 mother–child dyads that aims to investigate the effect of the environment on child health and development. Mercury (Hg), lead (Pb), cadmium (Cd), manganese (Mn) and selenium (Se) are considered to be important co-exposures when examining the effect of other chemical substances on child development. The levels of these elements in the blood of 20,000 randomly selected mid/late-term pregnant women from the whole JECS cohort were analysed using inductively coupled plasma-mass spectrometry. The median concentrations (interquartile ranges) for Pb, Hg, Cd, Mn and Se were 0.63 (0.51–0.78) µg dl−1, 3.83 (2.70–5.43) µg l−1, 0.70 (0.52–0.95) µg l−1, 16.1 (13.2–19.6) µg l−1 and 178 (165–192) µg l−1, respectively. Hg and Se correlated positively with each other (Spearman’s ρ = 0.287), as did Pb and Cd (ρ = 0.239) and Cd and Mn (ρ = 0.267). The blood Pb levels decreased by 5–10-fold over the past 25 years. The main predictors of the blood levels of each element were fish consumption for Hg, maternal age and non-alcoholic beverage consumption for Pb, maternal age and smoking for Cd, gestational age at sampling for Mn and serum protein levels for Se. These results revealed the historical trends and current predictors of the blood levels of these elements in pregnant Japanese women.
机译：日本环境与儿童研究（JECS）是一项针对100,000个母二倍体的出生队列研究，旨在研究环境对儿童健康和发育的影响。在检查其他化学物质对儿童发育的影响时，汞（Hg），铅（Pb），镉（Cd），锰（Mn）和硒（Se）被认为是重要的共同暴露。使用电感耦合等离子体质谱法分析了整个JECS队列中20,000名随机选择的中/晚期孕妇的血液中这些元素的水平。 Pb，Hg，Cd，Mn和Se的中位数浓度（四分位数范围）为0.63（0.51-0.78）µggdl -1 ，3.83（2.70-5.43）µggll -1 < /sup>、0.70（0.52-0.95）µg l -1 ，16.1（13.2-19.6）µg l -1 和178（165–192）µg l -1 。 Hg和Se呈正相关（Spearman的ρ= 0.287），Pb和Cd（ρ= 0.239）以及Cd和Mn（ρ= 0.267）也呈正相关。在过去的25年中，血铅水平下降了5-10倍。每种元素的血液水平的主要预测指标是：鱼类的汞摄入量，孕妇的年龄和铅的非酒精性饮料的摄入量，孕妇的镉摄入量和吸烟年龄，锰的孕龄和硒的血清蛋白水平。这些结果揭示了日本孕妇中这些元素的血液水平的历史趋势和当前预测因子。

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