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Adult Mouse Subventricular Zone Stem and Progenitor Cells Are Sessile and Epidermal Growth Factor Receptor Negatively Regulates Neuroblast Migration

机译：成年小鼠的脑室下区干细胞和祖细胞是无固定的和表皮生长因子受体负调控神经母细胞迁移。

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BackgroundThe adult subventricular zone (SVZ) contains stem and progenitor cells that generate neuroblasts throughout life. Although it is well accepted that SVZ neuroblasts are migratory, recent evidence suggests their progenitor cells may also exhibit motility. Since stem and progenitor cells are proliferative and multipotential, if they were also able to move would have important implications for SVZ neurogenesis and its potential for repair.

机译：背景成人的脑室下区（SVZ）包含干细胞和祖细胞，这些细胞在整个生命中都会产生神经母细胞。尽管人们普遍认为SVZ成神经细胞具有迁移性，但最近的证据表明它们的祖细胞也可能具有运动性。由于干细胞和祖细胞具有增殖能力和多能性，因此，如果它们也能够移动，将对SVZ神经发生及其修复潜力产生重要影响。

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期刊名称 PLoS Clinical Trials
作者
Yongsoo Kim; Isabelle Comte; Gabor Szabo; Philip Hockberger; Francis G. Szele;
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年(卷),期 2009(4),12
年度 2009
页码 e8122
总页数 13
原文格式 PDF
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专利

1. RE1 silencing transcription factoreuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro [J] . Soldati Chiara, Caramanica Pasquale, Burney Matthew J., Journal of Neuroscience Research . 2015,第8期

机译：RE1沉默转录因子/神经元限制性沉默因子调节成年小鼠脑室下区衍生的神经干/祖细胞的体外扩增
2. Sirolimus stimulates vascular stem/progenitor cell migration and differentiation into smooth muscle cells via epidermal growth factor receptor/extracellular signal-regulated kinase/β-catenin signaling pathway [J] . WongM.M., WinklerB., KaramaritiE., Arteriosclerosis, thrombosis, and vascular biology . 2013,第10期

机译：西罗莫司通过表皮生长因子受体/细胞外信号调节激酶/β-catenin信号通路刺激血管干/祖细胞迁移并分化为平滑肌细胞
3. cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice [J] . Hironobu Iguchi, Tetsuo Mitsui, Maho Ishida, Endocrine journal . 2011,第9期

机译：从成年小鼠前脑室下区分离的神经干细胞中，表皮生长因子（EGF）诱导的细胞增殖和血清反应元件激活需要cAMP反应元件结合蛋白（CREB）
4. Effects of Cutting the Olfactory Peduncle to Migration of Subventricular Zone Cells in Adult Rat [C] . Deguang Wang, Fengzhen Zhang Third International Conference of China on Anatomical Sciences Sep 21-24, 2001 Nantong, China . 2001

机译：切断嗅觉梗对成年大鼠脑室下区细胞迁移的影响
5. Cell migration and proliferation in postnatal murine subventricular zone neurogenesis: Roles of the epidermal growth factor receptor and dopamine receptor 3. [D] . Kim, Yongsoo. 2010

机译：产后鼠脑室下区神经发生中的细胞迁移和增殖：表皮生长因子受体和多巴胺受体的作用3。
6. Epidermal and Fibroblast Growth Factors Behave as Mitogenic Regulators for a Single Multipotent Stem Cell-Like Population from the Subventricular Region of the Adult Mouse Forebrain [O] . Angela Gritti, Paola Frölichsthal-Schoeller, Rossella Galli, 1999

机译：表皮和成纤维细胞生长因子作为成年调节剂从成年小鼠前脑室下的单个多能干细胞样群体。
7. Adult mouse subventricular zone stem and progenitor cells are sessile and epidermal growth factor receptor negatively regulates neuroblast migration. [O] . Kim, Y, Comte, I, Szabo, G, 2009

机译：成年小鼠的脑室下区干细胞和祖细胞是无柄的，表皮生长因子受体负调节神经母细胞的迁移。

Adult Mouse Subventricular Zone Stem and Progenitor Cells Are Sessile and Epidermal Growth Factor Receptor Negatively Regulates Neuroblast Migration

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