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Species-Specific Differences in the Expression of the HNF1A HNF1B and HNF4A Genes

机译：HNF1AHNF1B和HNF4A基因表达的物种特异性差异

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BackgroundThe HNF1A, HNF1B and HNF4A genes are part of an autoregulatory network in mammalian pancreas, liver, kidney and gut. The layout of this network appears to be similar in rodents and humans, but inactivation of HNF1A, HNF1B or HNF4A genes in animal models cause divergent phenotypes to those seen in man. We hypothesised that some differences may arise from variation in the expression profile of alternatively processed isoforms between species.

机译：背景HNF1A，HNF1B和HNF4A基因是哺乳动物胰腺，肝脏，肾脏和肠道中自动调节网络的一部分。该网络的布局在啮齿动物和人类中似乎是相似的，但是在动物模型中HNF1A，HNF1B或HNF4A基因的失活会导致与人类看到的表型不同。我们假设物种之间的交替加工同工型的表达谱变化可能会引起一些差异。

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期刊名称 PLoS Clinical Trials
作者
Lorna W. Harries; James E. Brown; Anna L. Gloyn;
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年(卷),期 2009(4),11
年度 2009
页码 e7855
总页数 7
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2. Novel Presentations of Congenital Hyperinsulinism due to Mutations in the MODY genes: HNF1A and HNF4A [J] . Diana E. Stanescu, Nkecha Hughes, Bernard Kaplan, The journal of clinical endocrinology and metabolism . 2012,第10期

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3. Double heterozygous mutations involving both HNF1A/MODY3 and HNF4A/MODY1 genes: a case report. [J] . Forlani G, Zucchini S, Di Rocco A, Diabetes care . 2010,第11期

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4. In-House Sequence Analysis of the GCK, HNF1A and HNF4A Genes for Diagnosis Confirmation of MODY: Identification of Two Novel Mutations [C] . Kok Siong Poon, Lily Chiu, Evelyn Siew Chuan Koay Molecular Medicine TRI-CON. . 2014

机译：用于诊断诊断确认的GCK，HNF1A和HNF4A基因的内部序列分析：鉴定两种新突变
5. Expression of uridinediphosphate glucuronosyltransferase genes: Focus on alternative splicing and transcriptional regulatory mechanisms that contribute to interindividual differences in drug and carcinogen metabolism. [D] . Jones, Nathan R. 2012

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6. Double Heterozygous Mutations Involving Both HNF1A/MODY3 and HNF4A/MODY1 Genes [O] . Gabriele Forlani, Stefano Zucchini, Antonio Di Rocco, 2010

机译：涉及HNF1A / MODY3和HNF4A / MODY1基因的双杂合突变
7. Species-specific differences in the expression of the HNF1A, HNF1B and HNF4A genes [O] . Harries, LW, Brown, JE, Gloyn, Anna L. 2013

机译：HNF1A，HNF1B和HNF4A基因表达的物种特异性差异

Species-Specific Differences in the Expression of the HNF1A HNF1B and HNF4A Genes

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