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Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway

机译：细胞凋亡过程中的几个核事件取决于Caspase-3激活但不构成共同途径

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A number of nuclear events occur during apoptosis, including DNA laddering, nuclear lamina breakdown, phosphorylation of histones H2B and histone H2AX, and the tight binding to chromatin of HMGB1 and CAD, the nuclease responsible for DNA laddering. We have performed an epistasis analysis to investigate whether these events cluster together in pathways. We find that all depend directly or indirectly on caspase-3 activation. CAD activation, H2AX phosphorylation and DNA laddering cluster together into a pathway, but all other events appear to be independent of each other downstream of caspase-3, and likely evolved subject to different functional pressures.

机译：细胞凋亡过程中发生了许多核事件，包括DNA梯形图，核层板破裂，组蛋白H2B和组蛋白H2AX的磷酸化以及与HMGB1和CAD的染色质的紧密结合，后者是负责DNA梯形图的核酸酶。我们进行了上位性分析，以调查这些事件是否在路径中聚集在一起。我们发现，所有这些都直接或间接取决于caspase-3的激活。 CAD激活，H2AX磷酸化和DNA阶梯化共同形成一条通路，但是所有其他事件似乎在caspase-3下游彼此独立，并且可能在不同的功能压力下发展。

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期刊名称 PLoS Clinical Trials
作者
Lisa Trisciuoglio; Marco Emilio Bianchi;
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年(卷),期 2009(4),7
年度 2009
页码 e6234
总页数 10
原文格式 PDF
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1. Nuclear caspase-3 and capase-7 activation, and poly(ADP-ribose) polymerase cleavage are early events in camptothecin-induced apoptosis [J] . Rodriguez-Hernandez A, Brea-Calvo G, Fernandez-Ayala DJM, Apoptosis: An international journal on programmed cell death . 2006,第1期

机译：核caspase-3和capase-7激活以及聚（ADP-核糖）聚合酶裂解是喜树碱诱导的细胞凋亡的早期事件
2. Diallyl Disulfide Induces Caspase-Dependent Apoptosis via Mitochondria-Mediated Intrinsic Pathway in B16F-10 Melanoma Cells by Up-Regulating P53, Caspase-3 and Down-Regulating Pro-Inflammatory Cytokines and Nuclear Factor- xbeta-Mediated Bcl-2 Activation [J] . P. Pratheeshkumar, P. Thejass, amp, Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer . 2010,第2期

机译：二烯丙基二硫通过上调P53，Caspase-3和下调促炎性细胞因子及核因子-xbeta介导的Bcl-2激活，通过线粒体介导的B16F-10黑色素瘤细胞内源性途径诱导Caspase依赖性凋亡。
3. Nipradilol inhibits apoptosis by preventing the activation of caspase-3 via S-nitrosylation and the cGMP-dependent pathway. [J] . Tomita H, Nakazawa T, Sugano E, European Journal of Pharmacology: An International Journal . 2002,第3期

机译：Nipradilol通过阻止caspase-3的S-亚硝基化和cGMP依赖性途径而抑制凋亡。
4. Vitamin C and N-Acetyl-L-cysteine prevent ethanol induced cultured cerebellar granule neurons apoptosis through Nuclear Factor-kappa B pathway [C] . Su Yang, Mao Jian, Lei Runhong, 2013 ICME International Conference on Complex Medical Engineering . 2013

机译：维生素C和N-乙酰-L-半胱氨酸通过核因子-κB途径阻止乙醇诱导的培养的小脑颗粒神经元凋亡
5. Mechanism of Caspase-3 Activation and MCL-1 Inhibition in the Regulation of Apoptosis [D] . Ponder, Katelyn G. 2018

机译：Caspase-3激活和MCL-1抑制在细胞凋亡调控中的作用机制
6. Liraglutide Protects Nucleus Pulposus Cells Against High-Glucose Induced Apoptosis by Activating PI3K/Akt/ mTOR/Caspase-3 and PI3K/Akt/GSK3β/Caspase-3 Signaling Pathways [O] . Mingyan Yao, Jing Zhang, Zhihong Li, 2021

机译：Liraglutide通过激活PI3K / AKT / MTOR / Caspase-3和PI3K / Akt /GSK3β/ Caspase-3信号通路来保护核骨盆细胞免受高葡萄糖诱导的细胞凋亡
7. Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway [O] . Trisciuoglio, Lisa, Bianchi, Marco Emilio 2009

机译：细胞凋亡过程中的几个核事件取决于Caspase-3激活，但不构成共同途径

Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway

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