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首页> 美国卫生研究院文献>PLoS Clinical Trials >Familial Resemblance of Borderline Personality Disorder Features: Genetic or Cultural Transmission?
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Familial Resemblance of Borderline Personality Disorder Features: Genetic or Cultural Transmission?

机译：边缘性人格障碍的家族相似特征：基因还是文化传播？

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Borderline personality disorder is a severe personality disorder for which genetic research has been limited to family studies and classical twin studies. These studies indicate that genetic effects explain 35 to 45% of the variance in borderline personality disorder and borderline personality features. However, effects of non-additive (dominance) genetic factors, non-random mating and cultural transmission have generally not been explored. In the present study an extended twin-family design was applied to self-report data of twins (N = 5,017) and their siblings (N = 1,266), parents (N = 3,064) and spouses (N = 939) from 4,015 families, to estimate the effects of additive and non-additive genetic and environmental factors, cultural transmission and non-random mating on individual differences in borderline personality features. Results showed that resemblance among biological relatives could completely be attributed to genetic effects. Variation in borderline personality features was explained by additive genetic (21%; 95% CI 17–26%) and dominant genetic (24%; 95% CI 17–31%) factors. Environmental influences (55%; 95% CI 51–60%) explained the remaining variance. Significant resemblance between spouses was observed, which was best explained by phenotypic assortative mating, but it had only a small effect on the genetic variance (1% of the total variance). There was no effect of cultural transmission from parents to offspring.
机译：交际型人格障碍是一种严重的人格障碍，遗传研究仅限于家庭研究和经典双胞胎研究。这些研究表明，遗传效应解释了边缘人格障碍和边缘人格特征变异的35％至45％。然而，通常没有探索非加性（显性）遗传因素，非随机交配和文化传播的影响。在本研究中，将扩展的双亲家庭设计应用于来自4,015个家庭的双胞胎（N = 5,017），其兄弟姐妹（N = 1,266），父母（N = 3,064）和配偶（N twin = 939）的自我报告数据，评估加性和非加性遗传和环境因素，文化传播和非随机交配对边界人格特征个体差异的影响。结果表明，生物学亲戚之间的相似性可以完全归因于遗传效应。边缘人格特征的变化可以通过累加遗传（21％； 95％CI 17–26％）和优势遗传（24％； 95％CI 17–31％）因素来解释。环境影响（55％； 95％CI 51-60％）解释了剩余的差异。观察到配偶之间存在明显的相似性，这可以通过表型分类交配来很好地解释，但是对遗传变异的影响很小（占总变异的1％）。从父母到后代的文化传播没有影响。

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