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Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial

机译：恶性疟原虫叮咬无菌疟原虫的疟原虫疟疾挑战：随机感染性试验的结果。

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BackgroundExperimental infection of malaria-naïve volunteers by the bite of Plasmodium falciparum-infected mosquitoes is a preferred means to test the protective effect of malaria vaccines and drugs. The standard model relies on the bite of five infected mosquitoes to induce malaria. We examined the efficacy of malaria transmission using mosquitoes raised aseptically in compliance with current Good Manufacturing Practices (cGMPs).

机译：背景技术恶性疟原虫感染的蚊子叮咬实验性地感染未疟疾的志愿者是测试疟疾疫苗和药物的保护作用的首选方法。标准模型依靠五只被感染的蚊子叮咬来诱发疟疾。我们检查了使用符合现行良好生产规范（cGMP）的无菌蚊子传播疟疾的功效。

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期刊名称 PLoS Clinical Trials
作者
Kirsten E. Lyke; Matthew Laurens; Matthew Adams; Peter F. Billingsley; Adam Richman; Mark Loyevsky; Sumana Chakravarty; Christopher V. Plowe; B. Kim Lee Sim; Robert Edelman; Stephen L. Hoffman;
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年(卷),期 2010(5),10
年度 2010
页码 e13490
总页数 10
原文格式 PDF
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专利

1. Use of polymerase chain reaction technique to confirm VecTest screening results in Plasmodium falciparum and Plasmodium vivax VK 210 laboratory-infected Anopheles stephensi mosquitoes. [J] . Santos Ciminera PD, Achee NL, Quinnan GV Jr, Journal of the American Mosquito Control Association. . 2004,第3期

机译：使用聚合酶链反应技术来确认恶性疟原虫和间日疟原虫VK 210在实验室感染的按蚊斯蒂芬斯蚊中的VecTest筛选结果。
2. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection [J] . Lattha Souvannaseng, Lewis Vibul Hun, Heather Baker, PLoS Pathogens . 2018,第11期

机译：对亚洲疟疾媒介按蚊中JNK信号的抑制可延长蚊子的寿命并提高对恶性疟原虫感染的抵抗力
3. Inhibition of JNK signaling in the Asian malaria vector Anopheles stephensi extends mosquito longevity and improves resistance to Plasmodium falciparum infection [J] . Lattha Souvannaseng, Lewis Vibul Hun, Heather Baker, PLoS Pathogens . 2018,第11期

机译：对亚洲疟疾媒介按蚊中JNK信号的抑制可延长蚊子的寿命并提高对恶性疟原虫感染的抵抗力
4. Identification and quantitation of Plasmodium falciparum and Anopheles gambiae proteins from Plasmodium parasite infected mosquitoes [C] . Raghothama Chaerkady, Mobolaji Okulate, Kumaran Kandasamy, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：来自疟原虫感染蚊子的疟原虫和anophelesGambiae蛋白的鉴定和定量。
5. Targeting Plasmodium falciparum in transgenic Anopheles stephensi mosquitoes with single-chain antibodies [D] . Isaacs, Alison Taylor 2011

机译：用单链抗体靶向转基因Stephensi蚊中的恶性疟原虫
6. Successful Human Infection with P. falciparum Using Three Aseptic Anopheles stephensi Mosquitoes: A New Model for Controlled Human Malaria Infection [O] . Matthew B. Laurens, Peter Billingsley, Adam Richman, -1

机译：成功的人类感染的恶性疟原虫使用三个无菌按蚊按蚊：控制人类疟疾感染的新模型。
7. Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial [O] . Lyke, Kirsten E., Laurens, Matthew, Adams, Matthew, 2010

机译：恶性疟原虫叮咬无菌疟原虫的疟原虫疟疾挑战：随机感染性试验的结果。

Plasmodium falciparum Malaria Challenge by the Bite of Aseptic Anopheles stephensi Mosquitoes: Results of a Randomized Infectivity Trial

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