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The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

机译：天然铜和锌结合蛋白金属硫蛋白阻止大鼠皮质神经元中铜介导的Aβ聚集和毒性。

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BackgroundA major pathological hallmark of AD is the deposition of insoluble extracellular β-amyloid (Aβ) plaques. There are compelling data suggesting that Aβ aggregation is catalysed by reaction with the metals zinc and copper.

机译：背景AD的主要病理特征是不溶性细胞外β-淀粉样蛋白（Aβ）斑块的沉积。有令人信服的数据表明，Aβ聚集是通过与金属锌和铜反应而催化的。

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期刊名称 PLoS Clinical Trials
作者
Roger S. Chung; Claire Howells; Emma D. Eaton; Lana Shabala; Kairit Zovo; Peep Palumaa; Rannar Sillard; Adele Woodhouse; William R. Bennett; Shannon Ray; James C. Vickers; Adrian K. West;
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年(卷),期 2010(5),8
年度 2010
页码 e12030
总页数 11
原文格式 PDF
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专利

1. Direct evidence for co-binding of cisplatin and cadmium to a native zinc- and cadmium-containing metallothionein [J] . Rupasri Mandal, Guifeng jiang, Xing-Fang Li Applied Organometallic Chemistry . 2003,第9期

机译：顺铂和镉与天然含锌和镉的金属硫蛋白共结合的直接证据
2. Zinc-, copper- and cadmium-binding protein in Ehrlich ascites tumour cells [J] . B Shankara, C F Shaw, D H Petering, The biochemical journal . 1980,第1期

机译：Ehrlich腹水肿瘤细胞中的锌，铜和镉结合蛋白
3. SULFUR K-EDGE EXAFS STUDIES OF CADMIUM-, ZINC-, COPPER-, AND SILVER-RABBIT LIVER METALLOTHIONEINS [J] . Gui Z., Kasrai M., Bancroft GM., Inorganic Chemistry: A Research Journal that Includes Bioinorganic, Catalytic, Organometallic, Solid-State, and Synthetic Chemistry and Reaction Dynamics . 1996,第22期

机译：镉，锌，铜和银兔子肝素中硫的K边缘暴露研究
4. Prion Protein Aggregation and Neurotoxicity in Cortical Neurons [C] . JOANA BARBOSA MELO, PAULA AGOSTINHO, CATARINA RESENDE OLIVEIRA Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：on蛋白在皮质神经元中的聚集和神经毒性
5. Exploring the role of protein phosphatase 5 in response to toxicity induced by amyloid-beta and oxidative stress in rat cortical neurons. [D] . Sanchez-Ortiz, Efrain. 2009

机译：探索蛋白磷酸酶5在淀粉样蛋白β诱导的毒性和大鼠皮质神经元的氧化应激反应中的作用。
6. Isolation and Characterization of Copper- and Zinc- Binding Metallothioneins from the Marine Alga Ulva compressa (Chlorophyta) [O] . Antonio Zúñiga, Daniel Laporte, Alberto González, 2020

机译：海藻Ulva compressa（Chlorophyta）中结合铜和锌的金属硫蛋白的分离和表征
7. The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons [O] . Chung, Roger S., Howells, Claire, Eaton, Emma D., 2010

机译：天然铜和锌结合蛋白金属硫蛋白阻止大鼠皮质神经元中铜介导的Aβ聚集和毒性。

The Native Copper- and Zinc- Binding Protein Metallothionein Blocks Copper-Mediated Aβ Aggregation and Toxicity in Rat Cortical Neurons

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