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首页> 美国卫生研究院文献>PLoS Clinical Trials >Resting State Functional Connectivity in Perfusion Imaging: Correlation Maps with BOLD Connectivity and Resting State Perfusion
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Resting State Functional Connectivity in Perfusion Imaging: Correlation Maps with BOLD Connectivity and Resting State Perfusion

机译：灌注成像中的静止状态功能连通性：具有大胆连通性和静止状态灌注的相关图

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摘要

Functional connectivity is a property of the resting state that may provide biomarkers of brain function and individual differences. Classically, connectivity is estimated as the temporal correlation of spontaneous fluctuations of BOLD signal. We investigated differences in connectivity estimated from the BOLD and CBF signal present in volumes acquired with arterial spin labeling technique in a large sample (N = 265) of healthy individuals. Positive connectivity was observable in both BOLD and CBF signal, and was present in the CBF signal also at frequencies lower than 0.009 Hz, here investigated for the first time. Negative connectivity was more variable. The validity of positive connectivity was confirmed by the existence of correlation across individuals in its intensity estimated from the BOLD and CBF signal. In contrast, there was little or no correlation across individuals between intensity of connectivity and mean perfusion levels, suggesting that these two biomarkers correspond to distinct sources of individual differences.
机译：功能连接性是静止状态的一种属性，可以提供脑功能和个体差异的生物标志物。传统上，将连通性估计为BOLD信号自发波动的时间相关性。我们调查了在健康个体的大样本（N == 265）中通过动脉自旋标记技术获得的体积中存在的BOLD和CBF信号估计的连通性差异。在BOLD和CBF信号中均可以观察到正连通性，并且在CBF信号中也存在低于0.009 Hz的频率，这是首次研究。负连通性更易变。通过BOLD和CBF信号估计的强度之间的相关性存在，从而证实了正连通性的有效性。相反，个体之间的连接强度和平均灌注水平之间几乎没有相关性，这表明这两个生物标志物对应于个体差异的不同来源。

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