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首页> 美国卫生研究院文献>PLoS Clinical Trials >Novel Arenavirus Sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: Implications for Evolution of Arenaviruses in Africa
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Novel Arenavirus Sequences in Hylomyscus sp. and Mus (Nannomys) setulosus from Côte d'Ivoire: Implications for Evolution of Arenaviruses in Africa

机译：Hylomyscus sp。中的新型球状病毒序列。和科特迪瓦的Mus（Nannomys）setulosus：对非洲盘状病毒进化的启示

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This study aimed to identify new arenaviruses and gather insights in the evolution of arenaviruses in Africa. During 2003 through 2005, 1,228 small mammals representing 14 different genera were trapped in 9 villages in south, east, and middle west of Côte d'Ivoire. Specimens were screened by pan-Old World arenavirus RT-PCRs targeting S and L RNA segments as well as immunofluorescence assay. Sequences of two novel tentative species of the family Arenaviridae, Menekre and Gbagroube virus, were detected in Hylomyscus sp. and Mus (Nannomys) setulosus, respectively. Arenavirus infection of Mus (Nannomys) setulosus was also demonstrated by serological testing. Lassa virus was not found, although 60% of the captured animals were Mastomys natalensis. Complete S RNA and partial L RNA sequences of the novel viruses were recovered from the rodent specimens and subjected to phylogenetic analysis. Gbagroube virus is a closely related sister taxon of Lassa virus, while Menekre virus clusters with the Ippy/Mobala/Mopeia virus complex. Reconstruction of possible virus–host co-phylogeny scenarios suggests that, within the African continent, signatures of co-evolution might have been obliterated by multiple host-switching events.
机译：这项研究旨在识别新的鼻病毒，并收集有关非洲鼻病毒进化的见解。在2003年至2005年期间，代表科特迪瓦南部，东部和中西部的9个村庄共捕获了代表14个不同属的1,228只小型哺乳动物。通过针对S和L RNA片段的pan-Old World arena病毒RT-PCR以及免疫荧光测定法筛选样本。在Hylomyscus sp。中检测到了两个新的暂定的沙眼病毒科物种Menekre和Gbagroube病毒。和Mus（Nannomys）setulosus。还通过血清学检测证明了粘液鼠（Man（Nannomys）setulosus）的病毒感染。尽管捕获的动物中有60％是纳塔氏菌，但未发现拉萨病毒。从啮齿动物的标本中回收了新病毒的完整S RNA和部分L RNA序列，并进行了系统发育分析。 Gbagroube病毒是与Lassa病毒密切相关的姊妹分类群，而Menekre病毒则聚集了Ippy / Mobala / Mopeia病毒复合体。可能的病毒-宿主共系统发生场景的重建表明，在非洲大陆内部，多个宿主切换事件可能已消除了共同进化的迹象。

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