• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>PLoS Clinical Trials >Functional Differences in the Backward Shifts of CA1 and CA3 Place Fields in Novel and Familiar Environments
【2h】

Functional Differences in the Backward Shifts of CA1 and CA3 Place Fields in Novel and Familiar Environments

机译：在新颖和熟悉的环境中，CA1和CA3放置字段向后移动的功能差异

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Insight into the processing dynamics and other neurophysiological properties of different hippocampal subfields is critically important for understanding hippocampal function. In this study, we compared shifts in the center of mass (COM) of CA3 and CA1 place fields in a familiar and completely novel environment. Place fields in CA1 and CA3 were simultaneously recorded as rats ran along a closed loop track in a familiar room followed by a session in a completely novel room. This process was repeated each day over a 4-day period. CA3 place fields shifted backward (opposite to the direction of motion of the rat) only in novel environments. This backward shift gradually diminished across days, as the novel environment became more familiar with repeated exposures. Conversely, CA1 place fields shifted backward across all days in both familiar and novel environments. Prior studies demonstrated that CA1 place fields on average do not exhibit a backward shift during the first exposure to an environment in which the familiar cues are rearranged into a novel configuration, although CA3 place fields showed a strong backward shift. Under the completely novel conditions of the present study, no dissociation was observed between CA3 and CA1 during the first novel session (although a strong dissociation was observed in the familiar sessions and the later novel sessions). In summary, this is the first study to use simultaneous recordings in CA1 and CA3 to compare place field COM shift and other associated properties in truly novel and familiar environments. This study further demonstrates functional differentiation between CA1 and CA3 as the plasticity of CA1 place fields is affected differently by exposure to a completely novel environment in comparison to an altered, familiar environment, whereas the plasticity of CA3 place fields is affected similarly during both types of environmental novelty.
机译：深入了解不同海马亚域的加工动力学和其他神经生理特性对于理解海马功能至关重要。在这项研究中，我们比较了在一个熟悉且完全新颖的环境中CA3和CA1放置场的质心（COM）的偏移。当大鼠沿着熟悉的房间中的闭环轨迹奔跑，然后在一个完全新颖的房间中进行训练时，同时记录了CA1和CA3中的位置字段。每天在4天的时间内重复此过程。 CA3放置场仅在新颖的环境中才向后移动（与大鼠的运动方向相反）。随着新型环境对反复曝光的逐渐熟悉，这种向后移动随着时间的推移逐渐减弱。相反，在熟悉的环境和新颖的环境中，CA1位置字段全天向后移动。先前的研究表明，尽管CA3放置场显示出强烈的向后偏移，但是在第一次暴露于熟悉的线索重新排列为新颖配置的环境中，CA1放置场平均不会显示出向后偏移。在本研究的完全新颖的条件下，在第一个新颖的会议期间未观察到CA3和CA1之间的解离（尽管在熟悉的会议和随后的新颖的会议中观察到了强烈的解离）。总而言之，这是第一项在CA1和CA3中使用同步记录来比较真正新颖和熟悉的环境中的位置场COM偏移和其他相关属性的研究。这项研究进一步证明了CA1和CA3之间的功能差异，因为与一个变化的，熟悉的环境相比，暴露于一个完全新颖的环境中，CA1场所的可塑性受到不同的影响，而CA3场所的可塑性在这两种类型的中都受到相似的影响环境新颖性。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号