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首页> 美国卫生研究院文献>PLoS Clinical Trials >Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Carboxylic Acids in CD-1 Mice
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Olfactory Sensitivity and Odor Structure-Activity Relationships for Aliphatic Carboxylic Acids in CD-1 Mice

机译：CD-1小鼠脂肪羧酸的嗅觉敏感性和气味结构-活性关系。

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摘要

Using a conditioning paradigm, the olfactory sensitivity of CD-1 mice for a homologous series of aliphatic n-carboxylic acids (ethanoic acid to n-octanoic acid) and several of their isomeric forms was investigated. With all 14 odorants, the animals significantly discriminated concentrations as low as 0.03 ppm (parts per million) from the solvent, and with four odorants the best-scoring animals even detected concentrations as low as 3 ppt (parts per trillion). Analysis of odor structure-activity relationships showed that the correlation between olfactory detection thresholds of the mice for the unbranched carboxylic acids and carbon chain length can best be described as a U-shaped function with the lowest threshold values at n-butanoic acid. A significant positive correlation between olfactory detection thresholds and carbon chain length of the carboxylic acids with their branching next to the functional carboxyl group was found. In contrast, no such correlation was found for carboxylic acids with their branching at the distal end of the carbon chain relative to the functional carboxyl group. Finally, a significant correlation was found between olfactory detection thresholds and the position of the branching of the carboxylic acids. Across-species comparisons suggest that mice are more sensitive for short-chained (C2 to C4) aliphatic n-carboxylic acids than other mammalian species, but not for longer-chained ones (C5 to C8). Further comparisons suggest that odor structure-activity relationships are both substance class- and species-specific.
机译：使用条件范式，研究了CD-1小鼠对一系列脂族正羧酸（乙酸对正辛酸）及其几种异构形式的嗅觉敏感性。在所有14种加味剂中，这些动物与溶剂的区别明显低至0.03 ppm（百万分之一），而在使用四种加味剂时，得分最高的动物甚至检测到低至3 ppt（每万亿分之一）的浓度。气味结构-活性关系的分析表明，对于直链羧酸而言，小鼠嗅觉检测阈值与碳链长度之间的相关性可以最好地描述为U型函数，其阈值在正丁酸处最低。发现嗅觉检测阈值与羧酸的碳链长度之间具有显着的正相关关系，且其支链紧邻功能性羧基。相反，对于羧酸，在碳链的远端相对于功能性羧基支化没有发现这种相关性。最后，发现嗅觉检测阈值与羧酸支链的位置之间存在显着的相关性。跨物种比较表明，小鼠对短链（C2至C4）脂族正羧酸的敏感性高于其他哺乳动物，但对长链（C5至C8）则不敏感。进一步的比较表明，气味结构与活性的关系既是物质类别的，也是物种特异性的。

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