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首页> 美国卫生研究院文献>PLoS Clinical Trials >Application of the Benchmark Dose (BMD) Method to Identify Thresholds of Cadmium-Induced Renal Effects in Non-Polluted Areas in China
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Application of the Benchmark Dose (BMD) Method to Identify Thresholds of Cadmium-Induced Renal Effects in Non-Polluted Areas in China

机译：基准剂量（BMD）方法在中国非污染地区识别镉诱发的肾脏效应阈值中的应用

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The benchmark dose (BMD) method has been increasingly used to assess the health risks of cadmium (Cd) in epidemiological studies. The aim of our study was to estimate the threshold levels of urinary Cd (UCd) using the BMD method in a general population of Jiangshan City, Zhejiang Province of China. In our study, a total of 934 people (469 men, 465 women) were recruited and morning urine samples were collected from all the participants. Levels of Cd, creatinine, and renal dysfunction indicators such as retinol binding protein (RBP), β2-microglobulin (β2-MG), and N-acetyl-b-glucosaminidase (NAG) in urine were detected for analysis of BMD and BMD low (BMDL) of UCd. RBP, β2-MG, and NAG in urine all correlated significantly (P < 0.001) with UCd except of age (P = 0.767). When the benchmark response (BMR) was 5%, the BMD/BMDL of UCd for RBP, β2-MG, and NAG was 1.69/ 0.89, 1.24/0.62, 0.85/0.49 μg/g Cr in men and 1.70/0.76, 1.35/0.64, 1.36/0.65 μg/g Cr in women, respectively. If the BMR was set at 10%, the BMD/BMDL of UCd for RBP, β2-MG, and NAG was 2.44/1.59, 2.09/1.30, 1.80/1.04 μg/g Cr in men and 2.43/1.53, 2.10/1.34, 2.31/1.37 μg/g Cr in women, respectively. Our results provided evidence for Cd-induced tubular effects in cadmium non-polluted areas in China. Both β2-MG and NAG were more sensitive than RBP in response to Cd exposure. But β2-MG was the most sensitive indicator in women, and NAG was the most sensitive one in men.
机译：在流行病学研究中，越来越多地使用基准剂量（BMD）方法评估镉（Cd）的健康风险。我们研究的目的是使用BMD方法估算中国浙江省江山市普通人群中尿Cd（UCd）的阈值水平。在我们的研究中，总共招募了934人（469名男性，465名女性），并从所有参与者中收集了早晨尿液样本。检测尿液中Cd，肌酐和肾功能不全指标（例如视黄醇结合蛋白（RBP），β2-微球蛋白（β2-MG）和N-乙酰-b-氨基葡萄糖苷酶（NAG））的含量，以分析BMD和BMD低（BMDL）的UCd。尿液中的RBP，β2-MG和NAG除年龄外均与UCd显着相关（P <0.001）（P = 0.767）。当基准响应（BMR）为5％时，男性RBP，β2-MG和NAG的UCd的BMD / BMDL为1.69 / 0.89、1.24 / 0.62、0.85 / 0.49μg/ g Cr，男性为1.70 / 0.76、1.35女性的Cr分别为/0.64、1.36/0.65μg/ g。如果BMR设置为10％，则男性RBP，β2-MG和NAG的UCd的BMD / BMDL为2.44 / 1.59、2.09 / 1.30、1.80 / 1.04μg/ g Cr（男性）和2.43 / 1.53、2.10 / 1.34女性的Cr分别为2.31 / 1.37μg/ g。我们的结果为镉在中国镉无污染地区引起的管状效应提供了证据。 β2-MG和NAG对Cd暴露的敏感性均高于RBP。但是，β2-MG是女性中最敏感的指标，而NAG是男性中最敏感的指标。

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