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首页> 美国卫生研究院文献>PLoS Clinical Trials >Novel systems for the application of isolated tensile, compressive, and shearing stimulation of distraction callus tissue
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Novel systems for the application of isolated tensile, compressive, and shearing stimulation of distraction callus tissue

机译：用于分离牵张，压缩和剪切刺激骨call组织的新型系统

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BackgroundDistraction osteogenesis is a procedure widely used for the correction of large bone defects. However, a high complication rate persists, likely due to insufficient stability during maturation. Numerical fracture healing models predict bone regeneration under different mechanical conditions allowing fixation stiffness optimization. However, most models apply a linear elastic material law inappropriate for the transient stresses/strains present during limb lengthening or segment transport. They are also often validated using in vivo osteotomy models lacking precise mechanical regulation due to the unavoidable stimulation of secondary interfragmentary motion during ambulation under finitely stiff fixation. Therefore, in order to create a robust numerical model of distraction osteogenesis, it is necessary to both characterize the new tissue’s viscoelasticity during distraction and determine the influence of strictly isolated stimulation in each loading mode (tension, compression, and shear) to account for potential differences in mechanical and histological response.
机译：背景牵引成骨术是广泛用于矫正大骨缺损的程序。但是，可能由于成熟期间稳定性不足而导致高并发症发生率。数值的骨折愈合模型可预测不同机械条件下的骨再生，从而优化固定硬度。但是，大多数模型应用的线性弹性材料定律不适用于肢体延长或节段运输过程中出现的瞬态应力/应变。还经常使用缺乏精确机械调节的体内截骨模型来验证它们，这是由于在有限的刚性固定下行走时不可避免地会刺激次碎片间运动。因此，为了创建健壮的牵张成骨的数值模型，既需要表征牵张过程中新组织的粘弹性，又要确定在每种加载模式（拉伸，压缩和剪切）下严格隔离的刺激的影响，以解决潜在的问题。机械和组织学反应的差异。

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