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首页> 美国卫生研究院文献>PLoS Clinical Trials >The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials
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The spectral features of EEG responses to transcranial magnetic stimulation of the primary motor cortex depend on the amplitude of the motor evoked potentials

机译：脑电对主运动皮层的经颅磁刺激的响应的频谱特征取决于运动诱发电位的幅度

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Transcranial magnetic stimulation (TMS) of the primary motor cortex (M1) can excite both cortico-cortical and cortico-spinal axons resulting in TMS-evoked potentials (TEPs) and motor-evoked potentials (MEPs), respectively. Despite this remarkable difference with other cortical areas, the influence of motor output and its amplitude on TEPs is largely unknown. Here we studied TEPs resulting from M1 stimulation and assessed whether their waveform and spectral features depend on the MEP amplitude. To this aim, we performed two separate experiments. In experiment 1, single-pulse TMS was applied at the same supra-threshold intensity on primary motor, prefrontal, premotor and parietal cortices and the corresponding TEPs were compared by means of local mean field power and time-frequency spectral analysis. In experiment 2 we stimulated M1 at resting motor threshold in order to elicit MEPs characterized by a wide range of amplitudes. TEPs computed from high-MEP and low-MEP trials were then compared using the same methods applied in experiment 1. In line with previous studies, TMS of M1 produced larger TEPs compared to other cortical stimulations. Notably, we found that only TEPs produced by M1 stimulation were accompanied by a late event-related desynchronization (ERD—peaking at ~300 ms after TMS), whose magnitude was strongly dependent on the amplitude of MEPs. Overall, these results suggest that M1 produces peculiar responses to TMS possibly reflecting specific anatomo-functional properties, such as the re-entry of proprioceptive feedback associated with target muscle activation.
机译：初级运动皮层（M1）的经颅磁刺激（TMS）可以激发皮质-皮质和皮质-脊髓轴突，分别产生TMS诱发电位（TEP）和电机诱发电位（MEP）。尽管与其他皮质区域存在显着差异，但电机输出及其振幅对TEP的影响仍然未知。在这里，我们研究了M1刺激产生的TEP，并评估了它们的波形和频谱特征是否取决于MEP振幅。为此，我们进行了两个单独的实验。在实验1中，将单脉冲TMS以相同的超阈值强度应用于初级运动，前额叶，运动前和顶叶皮层，并通过局部平均场功率和时频频谱分析比较了相应的TEP。在实验2中，我们在静止的运动阈值处刺激M1，以诱发以宽幅度范围为特征的MEP。然后，使用实验1中使用的相同方法比较从高MEP和低MEP试验计算得到的TEP。与先前的研究一致，与其他皮质刺激相比，M1的TMS产生更大的TEP。值得注意的是，我们发现只有M1刺激产生的TEP才伴有后期事件相关的失步（ERD，在TMS之后约300毫秒达到峰值），其幅度强烈取决于MEP的幅度。总体而言，这些结果表明M1对TMS产生特殊反应，可能反映了特定的解剖功能特性，例如与目标肌肉激活相关的本体感受反馈的重新进入。

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