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首页> 美国卫生研究院文献>PLoS Clinical Trials >Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids
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Activated carbon, a useful medium to bind chlordecone in soil and limit its transfer to growing goat kids

机译：活性炭，一种有用的介质，可将十氯酮结合在土壤中，并限制其转移到正在成长的山羊羔身上

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摘要

Chlordecone (Kepone) (CLD) is a highly persistent pesticide which was extensively used in the French West Indies; high levels of CLD can still currently be found in large agricultural areas. As CLD transfers from soil to animals mainly via involuntary ingestion, the consumption of foodstuffs derived from animals raised in contaminated areas may significantly contribute to exposure of humans to CLD. The present study was designed to test the efficacy of two different activated carbons (ACs) sources in limiting CLD transfer from soil to animal. Three soils (ASs) were prepared according to the OECD guideline 207. One standard soil (SS) lacking AC, and two modified preparations of SS supplemented with 2% coconut-based activated carbon (ORBO), SSO or with 2% lignite-based one (DARCO), SSD. All three soils were spiked with 10 μg of kepone per g of dry matter and aged for three weeks. This study involved 15 goat kids randomly assigned to the 3 experimental groups (n = 5/group), which were fed the experimental matrices at an exposure dose of 10 μg CLD per kg of body weight per day. After 21 d of oral exposure, CLD in adipose tissue and liver were analysed by LC-MS-MS. A significant decrease of 63.7% and 74.7% of CLD concentrations in adipose tissue and liver, respectively, were obtained from animals exposed using SS containing DARCO as compared to those receiving only SS. Decreases in CLD levels of 98.2% (adipose tissue) and 98.7% (liver) were obtained for animals exposed using SS containing ORBO. This study leads us to conclude that (i) the presence of AC in CLD-contaminated soil strongly reduces CLD bioavailability, and (ii) the efficacy depends on the nature and characteristics of the AC used.
机译：十氯酮（酮）是一种高度持久的农药，在法属西印度群岛广泛使用。目前在大型农业地区仍可发现高水平的CLD。由于CLD主要通过非自愿摄入从土壤转移到动物，因此食用受污染地区饲养的动物衍生的食品可能会极大地导致人类接触CLD。本研究旨在测试两种不同活性炭（AC）来源在限制CLD从土壤到动物的转移中的功效。根据OECD准则207制备了三种土壤（ASs）。一种不含AC的标准土壤（SS），以及两种SS的改良制剂，其中补充有2％的椰子基活性炭（ORBO），SSO或2％的褐煤基一台（DARCO）SSD。将每克干物质中的10种克酮酮掺入所有三种土壤中，并老化三周。这项研究涉及了15个随机分配到3个实验组（n = 5 /组）的山羊羔，他们每天以每公斤体重10μgCLD的暴露剂量喂食实验基质。口服21天后，通过LC-MS-MS分析脂肪组织和肝脏中的CLD。与仅接受SS的动物相比，使用含DARCO的SS暴露的动物在脂肪组织和肝脏中的CLD浓度分别显着降低了63.7％和74.7％。对于使用含SS的ORBO暴露的动物，其CLD水平分别降低了98.2％（脂肪组织）和98.7％（肝脏）。这项研究使我们得出以下结论：（i）受CLD污染的土壤中存在AC会大大降低CLD的生物利用度，并且（ii）功效取决于所用AC的性质和特性。

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