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首页> 美国卫生研究院文献>PLoS Clinical Trials >The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)
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The association between adult attained height and sitting height with mortality in the European Prospective Investigation into Cancer and Nutrition (EPIC)

机译：欧洲癌症与营养前瞻性调查（EPIC）中成人达到的身高和坐姿与死亡率之间的关系

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Adult height and sitting height may reflect genetic and environmental factors, including early life nutrition, physical and social environments. Previous studies have reported divergent associations for height and chronic disease mortality, with positive associations observed for cancer mortality but inverse associations for circulatory disease mortality. Sitting height might be more strongly associated with insulin resistance; however, data on sitting height and mortality is sparse. Using the European Prospective Investigation into Cancer and Nutrition study, a prospective cohort of 409,748 individuals, we examined adult height and sitting height in relation to all-cause and cause-specific mortality. Height was measured in the majority of participants; sitting height was measured in ~253,000 participants. During an average of 12.5 years of follow-up, 29,810 deaths (11,931 from cancer and 7,346 from circulatory disease) were identified. Hazard ratios (HR) with 95% confidence intervals (CI) for death were calculated using multivariable Cox regression within quintiles of height. Height was positively associated with cancer mortality (men: HRQ5 vs. Q1 = 1.11, 95%CI = 1.00–1.24; women: HRQ5 vs. Q1 = 1.17, 95%CI = 1.07–1.28). In contrast, height was inversely associated with circulatory disease mortality (men: HRQ5 vs. Q1 = 0.63, 95%CI = 0.56–0.71; women: HRQ5 vs. Q1 = 0.81, 95%CI = 0.70–0.93). Although sitting height was not associated with cancer mortality, it was inversely associated with circulatory disease (men: HRQ5 vs. Q1 = 0.64, 95%CI = 0.55–0.75; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.49–0.74) and respiratory disease mortality (men: HRQ5 vs. Q1 = 0.45, 95%CI = 0.28–0.71; women: HRQ5 vs. Q1 = 0.60, 95%CI = 0.40–0.89). We observed opposing effects of height on cancer and circulatory disease mortality. Sitting height was inversely associated with circulatory disease and respiratory disease mortality.
机译：成人的身高和坐姿可能反映了遗传和环境因素，包括生命早期的营养，身体和社会环境。先前的研究报道了身高和慢性疾病死亡率的相关性不同，癌症死亡率呈正相关，而循环系统疾病死亡率呈负相关。坐姿可能与胰岛素抵抗密切相关；但是，关于坐姿高度和死亡率的数据很少。使用欧洲前瞻性癌症和营养调查研究（前瞻性队列409,748人），我们检查了成年人身高和坐姿与所有原因和特定病因死亡率的关系。大部分参与者都测量了身高。坐姿高度约为253,000位参与者。在平均12.5年的随访期间，确定了29,810人死亡（11,931人死于癌症，7,346人死于循环系统疾病）。使用身高五分位数内的多变量Cox回归计算死亡风险比（HR）和95％置信区间（CI）。身高与癌症死亡率呈正相关（男性：HRQ5 vs. Q1 = 1.11，95％CI = 1.00-1.24；女性：HRQ5 vs. Q1 = 1.17，95％CI = 1.07-1.28）。相反，身高与循环系统疾病死亡率成反比（男性：HRQ5 vs. Q1 = 0.63，95％CI = 0.56-0.71；女性：HRQ5 vs. Q1 = 0.81，95％CI = 0.70-0.93）。尽管坐高与癌症死亡率无关，但与循环系统疾病呈负相关（男性：HRQ5 vs. Q1 = 0.64，95％CI = 0.55-0.75；女性：HRQ5 vs. Q1 = 0.60，95％CI = 0.49- 0.74）和呼吸系统疾病死亡率（男性：HRQ5 vs. Q1 = 0.45，95％CI = 0.28-0.71；女性：HRQ5 vs. Q1 = 0.60，95％CI = 0.40-0.89）。我们观察到身高对癌症和循环系统疾病死亡率的不利影响。坐姿与循环系统疾病和呼吸系统疾病的死亡率成反比。

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