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Exploring the risk of severe outcomes and the role of seasonal influenza vaccination in pregnant women hospitalized with confirmed influenza, Spain, 2010/11-2015/16

机译：2010 / 11-2015 / 16，西班牙，对于已确诊流感住院的孕妇，探讨严重后果的风险以及季节性流感疫苗接种的作用

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Based on previous observations during pandemics and seasonal epidemics, pregnant women are considered at risk of developing severe influenza outcomes after influenza infection. With the aim of preventing severe influenza illness, the World Health Organization (WHO) includes pregnant women as a target group for seasonal influenza vaccination. However, influenza vaccine uptake during pregnancy remains low in many countries, including Spain. The objectives of this study were to increase the evidence of pregnancy as a risk factor for severe influenza illness and to study the potential role of seasonal influenza vaccination in the prevention of severe outcomes in infected pregnant women. Using information from the surveillance of Severe Hospitalized Confirmed Influenza Cases (SHCIC) in Spain, from seasons 2010/11 to 2015/16, we estimated that pregnant women in our study had a relative risk of hospitalization with severe influenza nearly 7.8 times higher than non-pregnant women of reproductive age. Only 5 out of 167 pregnant women with known vaccination status in our study had been vaccinated (3.6%). Such extremely low vaccination coverage only allowed obtaining crude estimates suggesting a protective effect of the vaccine against influenza complications (ICU admission or death). Our overall results support that pregnant women could benefit from seasonal influenza vaccination, in line with national and international recommendations.
机译：根据大流行和季节性流行期间的先前观察，认为孕妇在感染流感后有发展严重流感的风险。为了预防严重的流感疾病，世界卫生组织（世卫组织）将孕妇列为季节性流感疫苗接种的目标人群。但是，在许多国家，包括西班牙，孕期流感疫苗的摄入量仍然很低。这项研究的目的是增加怀孕作为严重流感疾病危险因素的证据，并研究季节性流感疫苗在预防感染孕妇严重后果方面的潜在作用。使用来自西班牙的严重住院确诊流感病例（SHCIC）的监测信息，从2010/11到2015/16的季节，我们估计我们研究中的孕妇患重症流感的相对住院风险比未感染的人高近7.8倍-育龄妇女。在我们的研究中，在167位已知疫苗接种状况的孕妇中，只有5人接种了疫苗（3.6％）。如此低的疫苗接种覆盖率只能使人获得粗略的估计值，表明该疫苗具有预防流感并发症（ICU入院或死亡）的保护作用。我们的总体结果支持孕妇可以根据国家和国际建议从季节性流感疫苗接种中受益。

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