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首页> 美国卫生研究院文献>PLoS Clinical Trials >Pre-sleep treatment with galantamine stimulates lucid dreaming: A double-blind, placebo-controlled, crossover study
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Pre-sleep treatment with galantamine stimulates lucid dreaming: A double-blind, placebo-controlled, crossover study

机译：加兰他敏的睡前治疗刺激了清醒梦：一项双盲，安慰剂对照，交叉研究

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Lucid dreaming is a remarkable state of consciousness in which one is aware of the fact that one is dreaming while continuing to dream. Based on the strong relationship between physiological activation during rapid eye-movement sleep and lucid dreaming, our pilot research investigated whether enhancing cortical activation via acetylcholinesterease inhibition (AChEI) would increase the frequency of lucid dreams and found AChEI to be a promising method for lucid dream induction. In the current study we sought to quantify the size and reliability of the effect of AChEI on lucid dreaming, dream recall and dream content as well as to test the effectiveness of an integrated lucid dream induction protocol which combined cholinergic stimulation with other methods for lucid dream induction. Participants (N = 121) with high dream recall and an interest in lucid dreaming were randomly assigned counterbalanced orders of 3 doses of galantamine (0, 4 and 8 mg). On 3 consecutive nights, they awoke approximately 4.5 hours after lights out, recalled a dream, ingested the capsules and stayed out of bed for at least 30 minutes. Participants then returned to bed and practiced the Mnemonic Induction of Lucid Dreams technique while returning to sleep. The percentage of participants who reported a lucid dream was significantly increased for both 4 mg (27%, odds ratio = 2.29) and 8 mg doses (42%, odds ratio = 4.46) compared to the active placebo procedure (14%). Galantamine also significantly increased dream recall, sensory vividness and complexity (p<0.05). Dream recall, cognitive clarity, control, positive emotion, vividness and self-reflection were increased during lucid compared to non-lucid dreams (p<0.0001). These results show that galantamine increases the frequency of lucid dreams in a dose-related manner. Furthermore, the integrated method of taking galantamine in the last third of the night with at least 30 minutes of sleep interruption and with an appropriately focused mental set is one of the most effective methods for inducing lucid dreams available today.
机译：清醒梦是一种非凡的意识状态，其中人们意识到一个人在继续做梦的同时在做梦的事实。基于快速眼动睡眠中的生理激活与清醒梦之间的密切关系，我们的先导研究调查了通过乙酰胆碱酯酶抑制（AChEI）增强皮质激活是否会增加清醒梦的频率，并发现AChEI是一种有希望实现清醒梦的方法感应。在本研究中，我们试图量化AChEI对清醒梦，梦回想和梦境内容的影响的大小和可靠性，以及测试将胆碱能刺激与其他方法结合用于清醒梦的综合清醒梦诱导方案的有效性感应。参加者（N = 121）具有较高的梦境回忆和对清醒梦的兴趣，被随机分配了3剂量的加兰他敏（0、4和8毫克）的平衡配比顺序。在连续3个晚上，他们在熄灯后约4.5个小时醒来，回忆起一个梦，摄取了这些胶囊并在床上呆了至少30分钟。然后，参与者回到床上，并在入睡时练习了“清醒梦的助记法”技术。与有效的安慰剂程序（14％）相比，服用4 mg（27％，比值比= 2.29）和8 mg剂量（42％，比值比= 4.46）的人都报告了清醒梦的百分比显着增加。加兰他敏还显着增加了梦境回忆，感觉生动度和复杂性（p <0.05）。与非清醒梦相比，清醒梦的回忆，认知清晰度，控制力，积极情绪，生动和自我反省都增加了（p <0.0001）。这些结果表明，加兰他敏以剂量相关的方式增加了清醒梦的发生频率。此外，在晚上的最后三分之内服用加兰他敏，至少有30分钟的睡眠中断并具有适当集中精神状态的综合方法，是当今诱导清醒梦的最有效方法之一。

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