• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>PLoS Clinical Trials >Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia
【2h】

Changes in lipid metabolism and capillary density of the skeletal muscle following low-intensity exercise training in a rat model of obesity with hyperinsulinemia

机译：低强度运动训练对高胰岛素血症肥胖大鼠模型骨骼肌脂质代谢和骨骼肌毛细血管密度的变化

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Although exercise is effective in improving obesity and hyperinsulinemia, the exact influence of exercise on the capillary density of skeletal muscles remains unknown. The aim of this study was to investigate the effects of low-intensity exercise training on metabolism in obesity with hyperinsulinemia, focusing specifically on the capillary density within the skeletal muscle. Otsuka Long-Evans Tokushima fatty (OLETF) rats were used as animal models of obesity with hyperinsulinemia, whereas Long-Evans Tokushima Otsuka (LETO) rats served as controls (no obesity, no hyperinsulinemia). The animals were randomly assigned to either non-exercise or exercise groups (treadmill running for 60 min/day, for 4 weeks). The exercise groups were further divided into subgroups according to training mode: single bout (60 min, daily) vs. multiple bout (three bouts of 20 min, daily). Fasting insulin levels were significantly higher in OLETF than in LETO rats. Among OLETF rats, there were no significant differences in fasting glucose levels between the exercise and the non-exercise groups, but the fasting insulin levels were significantly lower in the exercise group. Body weight and triacylglycerol levels in the liver were significantly higher in OLETF than in LETO rats; however, among OLETF rats, these levels were significantly lower in the exercise than in the non-exercise group. The capillary-to-fiber ratio of the soleus muscle was significantly higher in OLETF than in LETO rats; however, among OLETF rats, the ratio was lower in the exercise group than in the non-exercise group. No significant differences in any of the studied parameters were noted between the single-bout and multiple-bout exercise training modes among either OLETF or LETO rats. These results suggest that low-intensity exercise training improves insulin sensitivity and fatty liver. Additionally, the fact that attenuation of excessive capillarization in the skeletal muscle of OLETF rats was accompanied by improvement in increased body weight.
机译：尽管运动可以有效改善肥胖症和高胰岛素血症，但运动对骨骼肌毛细血管密度的确切影响仍然未知。这项研究的目的是研究低强度运动训练对高胰岛素血症肥胖症患者新陈代谢的影响，特别是骨骼肌内的毛细血管密度。大冢长埃文斯德岛肥胖（OLETF）大鼠被用作肥胖高胰岛素血症的动物模型，而长埃文斯德岛大冢（LETO）大鼠则作为对照（无肥胖，无高胰岛素血症）。将动物随机分为非运动组或运动组（跑步机每天运行60分钟，持续4周）。根据训练方式将运动组进一步分为亚组：单轮（每天60分钟）与多轮（每天20分钟的三轮）。 OLETF中的空腹胰岛素水平明显高于LETO大鼠。在OLETF大鼠中，运动组和非运动组之间的空腹血糖水平无显着差异，但运动组的空腹胰岛素水平显着降低。 OLETF中肝脏的体重和三酰甘油水平显着高于LETO大鼠。但是，在OLETF大鼠中，这些水平在运动中显着低于非运动组。比起LETO大鼠，OLETF中比目鱼肌的毛细比明显增加。然而，在OLETF大鼠中，运动组的比例低于非运动组。在OLETF或LETO大鼠中，单轮和多轮运动训练模式之间的任何研究参数均无显着差异。这些结果表明，低强度运动训练可改善胰岛素敏感性和脂肪肝。此外，OLETF大鼠骨骼肌过度毛细血管化的减轻伴随着体重增加的改善。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号