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首页> 美国卫生研究院文献>PLoS Clinical Trials >Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces
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Probiotic and anti-inflammatory potential of Lactobacillus rhamnosus 4B15 and Lactobacillus gasseri 4M13 isolated from infant feces

机译：从婴儿粪便中分离出鼠李糖乳杆菌4B15和加氏乳杆菌4M13的益生菌和抗炎潜力

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A total of 22 Lactobacillus strains, which were isolated from infant feces were evaluated for their probiotic potential along with resistance to low pH and bile salts. Eight isolates (L. reuteri 3M02 and 3M03, L. gasseri 4M13, 4R22, 5R01, 5R02, and 5R13, and L. rhamnosus 4B15) with high tolerance to acid and bile salts, and ability to adhere to the intestine were screened from 22 strains. Further, functional properties of 8 Lactobacillus strains, such as anti-oxidation, inhibition of α-glucosidase activity, cholesterol-lowering, and anti-inflammation were evaluated. The properties were strain-specific. Particularly, two strains of L. rhamnosus, 4B15 (4B15) and L. gasseri 4M13 (4M13) showed considerably higher anti-oxidation, inhibition of α-glucosidase activity, and cholesterol-lowering, and greater inhibition of nitric oxide production than other strains. Moreover, the two selected strains substantially inhibited the release of inflammatory mediators such as TNF-α, IL-6, IL-1β, and IL-10 stimulated the treatment of RAW 264.7 macrophages with LPS. In addition, whole genome sequencing and comparative genomic analysis of 4B15 and 4M13 indicated them as novel genomic strains. These results suggested that 4B15 and 4M13 showed the highest probiotic potential and have an impact on immune health by modulating pro-inflammatory cytokines.
机译：从婴儿粪便中分离出的总共22株乳酸杆菌菌株被评估了其益生菌潜力以及对低pH和胆汁盐的抗性。从22种细菌中筛选出8种对酸和胆汁盐具有高耐受性的菌株（罗伊氏乳杆菌3M02和3M03，加氏乳杆菌4M13、4R22、5R01、5R02和5R13和鼠李糖乳杆菌4B15）。株。此外，评价了8种乳酸杆菌菌株的功能特性，例如抗氧化，抑制α-葡萄糖苷酶活性，降低胆固醇和抗发炎。这些性质是应变特异性的。特别是，鼠李糖乳杆菌的两个菌株4B15（4B15）和盖氏乳杆菌4M13（4M13）表现出比其他菌株更高的抗氧化性，α-葡萄糖苷酶活性的抑制和胆固醇的降低以及一氧化氮生成的更大抑制。 。而且，两个选择的菌株基本上抑制了炎性介质的释放，例如TNF-α，IL-6，IL-1β和IL-10刺激了LPS对RAW 264.7巨噬细胞的治疗。另外，全基因组测序和4B15和4M13的比较基因组分析表明它们是新的基因组菌株。这些结果表明4B15和4M13表现出最高的益生菌潜力，并通过调节促炎性细胞因子对免疫健康产生影响。

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