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A Dopaminergic Gene Cluster in the Prefrontal Cortex Predicts Performance Indicative of General Intelligence in Genetically Heterogeneous Mice

机译:前额叶皮层中的多巴胺能基因簇可预测遗传异质小鼠的一般智力表现

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摘要

BackgroundGenetically heterogeneous mice express a trait that is qualitatively and psychometrically analogous to general intelligence in humans, and as in humans, this trait co-varies with the processing efficacy of working memory (including its dependence on selective attention). Dopamine signaling in the prefrontal cortex (PFC) has been established to play a critical role in animals' performance in both working memory and selective attention tasks. Owing to this role of the PFC in the regulation of working memory, here we compared PFC gene expression profiles of 60 genetically diverse CD-1 mice that exhibited a wide range of general learning abilities (i.e., aggregate performance across five diverse learning tasks).
机译:背景技术遗传上异质的小鼠在性质和心理上都表现出与人类一般智力类似的特质,并且与人类一样,该特质与工作记忆的加工功效(包括其对选择性注意的依赖性)共变。已经建立了前额叶皮层(PFC)中的多巴胺信号传导,以在动物的工作记忆和选择性注意任务中发挥关键作用。由于PFC在调节工作记忆中的这种作用,在这里我们比较了60种遗传多样的CD-1小鼠的PFC基因表达谱,这些CD-1小鼠表现出广泛的一般学习能力(即在五种多样的学习任务中的综合表现)。

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