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首页> 美国卫生研究院文献>Redox Biology >Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health
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Blood cell respirometry is associated with skeletal and cardiac muscle bioenergetics: Implications for a minimally invasive biomarker of mitochondrial health

机译：血细胞呼吸测定法与骨骼肌和心肌生物能相关：线粒体健康微创生物标志物的含义

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Blood based bioenergetic profiling strategies are emerging as potential reporters of systemic mitochondrial function; however, the extent to which these measures reflect the bioenergetic capacity of other tissues is not known. The premise of this work is that highly metabolically active tissues, such as skeletal and cardiac muscle, are susceptible to differences in systemic bioenergetic capacity. Therefore, we tested whether the respiratory capacity of blood cells, monocytes and platelets, are related to contemporaneous respirometric assessments of skeletal and cardiac muscle mitochondria. 18 female vervet/African green monkeys (Chlorocebus aethiops sabaeus) of varying age and metabolic status were examined for this study. Monocyte and platelet maximal capacity correlated with maximal oxidative phosphorylation capacity of permeabilized skeletal muscle (R=0.75, 95% confidence interval [CI]: 0.38–0.97; R=0.51, 95%CI: 0.05–0.81; respectively), isolated skeletal muscle mitochondrial respiratory control ratio (RCR; R=0.70, 95%CI: 0.35–0.89; R=0.64, 95%CI: 0.23–0.98; respectively), and isolated cardiac muscle mitochondrial RCR (R=0.55, 95%CI: 0.22–0.86; R=0.58, 95%CI: 0.22–0.85; respectively). These results suggest that blood based bioenergetic profiling may be used to report on the bioenergetic capacity of muscle tissues. Blood cell respirometry represents an attractive alternative to tissue based assessments of mitochondrial function in human studies based on ease of access and the minimal participant burden required by these measures.
机译：基于血液的生物能谱分析策略正逐渐成为全身线粒体功能的潜在报道者。然而，这些措施在多大程度上反映了其他组织的生物能能力尚不清楚。这项工作的前提是，具有高代谢活性的组织（例如骨骼肌和心肌）易受系统生物能能力差异的影响。因此，我们测试了血细胞，单核细胞和血小板的呼吸能力是否与骨骼和心肌线粒体的同期呼吸测定有关。本研究检查了18只不同年龄和新陈代谢状态的雌性黑尾猴/非洲绿猴（Chlorocebus aethiops sabaeus）。单核细胞和血小板的最大容量与透化的骨骼肌的最大氧化磷酸化能力相关（R = 0.75，95％置信区间[CI]：0.38-0.97； R = 0.51，95％CI：0.05-0.81；分别为骨骼肌）线粒体呼吸控制比（RCR； R = 0.70，95％CI：0.35-0.89； R = 0.64，95％CI：0.23-0.98；）和孤立的心肌线粒体RCR（R = 0.55，95％CI：0.22） –0.86； R = 0.58，95％CI：0.22-0.85；分别）。这些结果表明，基于血液的生物能谱可用于报告肌肉组织的生物能能力。血细胞呼吸测定法是基于人体组织中对线粒体功能的基于组织的评估的一种有吸引力的替代方法，该评估基于易于获取和这些措施所需的最小参与者负担。

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