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Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial

机译：基于峰谷与基于谷的万古霉素治疗药物监测方法的临床和药代动力学结果：实用随机对照试验

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BackgroundVancomycin therapeutic drug monitoring (TDM) is based on achieving 24-h area under the concentration–time curve to minimum inhibitory concentration cure breakpoints (AUC24/MIC). Approaches to vancomycin TDM vary, with no head-to-head randomized controlled trial (RCT) comparisons to date.

机译：背景万古霉素治疗药物监测（TDM）是基于在浓度-时间曲线下达到24小时面积至最小抑制浓度治愈断点（AUC24 / MIC）。万古霉素TDM的方法各不相同，迄今为止尚无头对头随机对照试验（RCT）比较。

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期刊名称 Springer Open Choice
作者
Fatima Khalifa Al-Sulaiti; Ahmed Mohamed Nader; Mohamed Omar Saad; Adila Shaukat; Rakesh Parakadavathu; Ahmed Elzubair; Daoud Al-Badriyeh; Hazem Elewa; Ahmed Awaisu;
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年(卷),期 -1(44),5
年度 -1
页码 639–652
总页数 14
原文格式 PDF
正文语种
中图分类外科学;
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专利

1. Clinical and Pharmacokinetic Outcomes of Peak-Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial [J] . Al-Sulaiti Fatima Khalifa, Nader Ahmed Mohamed, Saad Mohamed Omar, European journal of drug metabolism and pharmacokinetics . 2019,第5期

机译：基于峰值基于谷胱碱的万古霉素治疗药物监测方法的临床和药代动力学结果：务实的随机对照试验
2. An open-label, pragmatic, randomized controlled clinical trial to evaluate the comparative effectiveness of daptomycin versus vancomycin for the treatment of complicated skin and skin structure infection [J] . Teresa L Kauf, Peggy McKinnon, G. R Corey, BMC Infectious Diseases . 2015,第1期

机译：开放性，实用，随机对照临床试验，评估达托霉素与万古霉素治疗复杂皮肤和皮肤结构感染的比较效果
3. Therapeutic drug monitoring of docetaxel by pharmacokinetics and pharmacogenetics: A randomized clinical trial of AUC‐guided dosing in nonsmall cell lung cancer [J] . Yuxiang Ma, Xin Zhao, Xi Chen, Clinical and Translational Medicine . 2021,第4期

机译：药代动力学和药物生物学的治疗药物监测：Nonsmall细胞肺癌中AUC引导给药的随机临床试验
4. Clinical Trial of Recombinant Human PH20 Hyaluronidase's Effect on Subcutaneous Absorption and Pharmacokinetics of a Large Protein Molecule Therapeutic [C] . Richard C. Yocum, Daniel E. Vaughn, Deborah J. Mongiovi, Controlled Release Society Annual Meeting and Exposition . 2007

机译：重组人PH20透明质酸酶对大蛋白分子皮下吸收和药代动力学的影响的临床试验
5. A 4-month randomized controlled clinical trial of adjuvant Exenatide or Pramlintide versus insulin alone in pediatric type 1 diabetes mellitus: Effect on glycemic control. [D] . Withycombe, Sarah Elizabeth. 2010

机译：儿科1型糖尿病患者中艾塞那肽或普兰林肽与单独使用胰岛素的4个月随机对照临床试验：对血糖控制的影响。
6. The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial [O] . A. Abdulla, T. M. J. Ewoldt, N. G. M. Hunfeld, 2020

机译：β-内酰胺和氟喹诺酮类药物治疗药物监测对危重患者临床结局的影响：多中心随机对照试验的DOLPHIN试验方案
7. The effect of therapeutic drug monitoring of beta-lactam and fluoroquinolones on clinical outcome in critically ill patients: the DOLPHIN trial protocol of a multi-centre randomised controlled trial [O] . A. Abdulla, T. M. J. Ewoldt, N. G. M. Hunfeld, 2020

机译：β-内酰胺和氟喹诺酮类药物监测对危重病患者临床结果的治疗药物监测：多中心随机对照试验的海豚试验方案

Clinical and Pharmacokinetic Outcomes of Peak–Trough-Based Versus Trough-Based Vancomycin Therapeutic Drug Monitoring Approaches: A Pragmatic Randomized Controlled Trial

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