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Can the world’s favorite fruit tomato provide an effective biosynthetic chassis for high-value metabolites?

机译:世界上最喜欢的水果西红柿能否为高价值代谢物提供有效的生物合成基础?

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摘要

Tomato has a relatively short growth cycle (fruit ready to pick within 65–85 days from planting) and a relatively high yield (the average for globe tomatoes is 3–9 kg fruit per plant rising to as much as 40 kg fruit per plant). Tomatoes also produce large amounts of important primary and secondary metabolites which can serve as intermediates or substrates for producing valuable new compounds. As a model crop, tomato already has a broad range of tools and resources available for biotechnological applications, either increased nutrients for health-promoting biofortified foods or as a production system for high-value compounds. These advantages make tomato an excellent chassis for the production of important metabolites. We summarize recent achievements in metabolic engineering of tomato and suggest new candidate metabolites which could be targets for metabolic engineering. We offer a scheme for how to establish tomato as a chassis for industrial-scale production of high-value metabolites.
机译:番茄的生长周期相对较短(在种植后65-85天内可以采摘的果实)且产量较高(全球番茄的平均产量为每株植物3-9公斤水果,每株植物最多可增加40公斤水果) 。番茄还产生大量重要的主要和次要代谢产物,可作为生产有价值的新化合物的中间体或底物。作为标准作物,番茄已经拥有可用于生物技术应用的广泛工具和资源,既可以增加营养以促进健康的生物强化食品,也可以作为高价值化合物的生产系统。这些优点使番茄成为生产重要代谢产物的极佳底盘。我们总结了番茄代谢工程的最新成就,并提出了可能成为代谢工程目标的新候选代谢产物。我们提供了一个计划,以建立番茄为工业规模生产高价值代谢物的基础。

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