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首页> 美国卫生研究院文献>Springer Open Choice >Hydrogeochemical and biomedical insights into germanium potential of curative waters: a case study of health resorts in the Sudetes Mountains (Poland)
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Hydrogeochemical and biomedical insights into germanium potential of curative waters: a case study of health resorts in the Sudetes Mountains (Poland)

机译：治愈性水的锗潜力的水文地球化学和生物医学见解：以苏德特斯山脉（波兰）疗养胜地为例

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Germanium is considered to be a non-essential element; however, little is still known about its significance for living organisms. It exerts prophylactic and therapeutic effects in the treatment of serious diseases such as cancer, HIV infection, and others. Germanium does not exhibit acute toxicity, but, as it tends to accumulate in various organs and tissues, undesirable and even dangerous side effects have been reported after prolonged and/or high dosage application. In general, inorganic compounds of germanium are more toxic than its organic compounds. Further studies should be performed to elucidate the exact molecular mechanism of germanium action, to determine the safe and effective dose of germanium via curative/mineral waters, and to understand the applications and benefits of using germanium-enriched waters in balneotherapy. The geochemistry of curative (cold CO2-rich, thermal) waters from spas in the Sudetes (Poland) was clarified in terms of components and mineral phases which might govern germanium. Germanium and silicon in thermal (above 20 °C) waters presumably result from the solubility of silicates in crystalline (granites, gneisses) aquifer rocks and might be controlled by neo-formed quartz. The cold CO2-rich waters revealed a significant diversity of aqueous chemistry and relationships of germanium with iron, silicon, or arsenic. Locally, both in sedimentary (sandstones) and metamorphic (gneisses) aquifer rocks, primary (silicates) and/or secondary (oxides) iron-containing minerals likely release germanium into solution. In the CO2-rich waters of the western part of the Kłodzko Region, germanium distinctly correlates with arsenic. It is hypothesized that both elements are co-sourced from crystalline basement and/or migration of substances of post-magmatic origin along deep-seated dislocations related to the seismically active Poříčí-Hronov fault zone. This area was proposed as the most prospective one for finding waters rich in germanium in the Sudetes.Electronic supplementary materialThe online version of this article (10.1007/s10653-017-0061-0) contains supplementary material, which is available to authorized users.
机译：锗被认为是非必需元素；然而，对于其对于活生物体的重要性还知之甚少。它在癌症，HIV感染等严重疾病的治疗中具有预防和治疗作用。锗没有表现出急性毒性，但是，由于它倾向于在各种器官和组织中积累，因此在长期和/或高剂量应用后，已经报告了不良的甚至有害的副作用。通常，锗的无机化合物比其有机化合物毒性更大。应该进行进一步的研究，以阐明锗作用的确切分子机制，确定通过治疗性/矿泉水的安全有效剂量的锗，并了解在锗疗法中使用富含锗的水的应用和益处。在苏台特斯（波兰）的温泉中，治疗性（富含CO2的冷热水）水的地球化学在可能控制锗的成分和矿物相方面得到了阐明。锗（在20°C以上）中的硅和硅可能是硅酸盐在结晶性（花岗岩，片麻岩）含水层岩石中的溶解度造成的，并且可能由新形成的石英控制。富含CO2的冷水揭示了水化学的多样性以及锗与铁，硅或砷之间的关系。就局部而言，在沉积（砂岩）和变质（片麻岩）含水层岩石中，含铁的初级（硅酸盐）和/或次级（氧化物）矿物质都可能将锗释放到溶液中。在Kodzko地区西部富含CO2的水域中，锗与砷明显相关。据推测，这两种元素是共同源于晶体基底和/或后岩浆成因物质沿与地震活跃的波日奇-霍罗诺夫断裂带有关的深层位错的迁移。该区域被提议为在Sudetes中寻找富含锗的水域的最有前景的区域。电子补充材料本文的在线版本（10.1007 / s10653-017-0061-0）包含补充材料，授权用户可以使用。

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