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首页> 美国卫生研究院文献>Springer Open Choice >Meeting report of the 8th International Conference on cGMP cGMP: generators effectors and therapeutic implications at Bamberg Germany from June 23 to 25 2017
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Meeting report of the 8th International Conference on cGMP cGMP: generators effectors and therapeutic implications at Bamberg Germany from June 23 to 25 2017

机译：2017年6月23日至25日在德国班贝格召开的第八届cGMP国际会议 cGMP：发生器效应子和治疗意义会议报告

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Although the Nobel Prize for the discovery of nitric oxide (NO) dates back almost 20 years now, the knowledge about cGMP signaling is still constantly increasing. It looks even so that our understanding of the role of the soluble guanylyl cyclase (sGC) and particulate guanylyl cyclase (pGC) in health and disease is in many aspects at the beginning and far from being understood. This holds even true for the therapeutic impact of innovative drugs acting on both the NO/sGC and the pGC pathways. Since cGMP, as second messenger, is involved in the pathogenesis of numerous diseases within the cardiovascular, pulmonary, renal, and endocrine systems and also plays a role in neuronal, sensory, and tumor processes, drug applications might be quite broad. On the 8th International Conference on cGMP, held in Bamberg, Germany, world leading experts came together to discuss these topics. All aspects of cGMP research from the basic understanding of cGMP signaling to clinical applicability were discussed in depth. In addition, present and future therapeutic applications of cGMP-modulating pharmacotherapy were presented ().
机译：尽管诺贝尔奖获得者一氧化氮（NO）的发现可以追溯到20年前，但有关cGMP信号的知识仍在不断增加。看起来，甚至我们对可溶性鸟嘌呤环化酶（sGC）和微粒鸟嘌呤环化酶（pGC）在健康和疾病中的作用的了解在许多方面都处于起步阶段，而且远未得到理解。对于同时作用于NO / sGC和pGC途径的创新药物的治疗效果而言，也是如此。由于cGMP作为第二信使，参与了心血管，肺，肾和内分泌系统内多种疾病的发病机制，并且在神经元，感觉和肿瘤过程中也发挥着作用，因此药物的应用可能非常广泛。在德国班贝格举行的第八届cGMP国际会议上，世界领先的专家聚集在一起讨论了这些主题。从对cGMP信号的基本了解到临床适用性，对cGMP研究的各个方面进行了深入讨论。此外，还介绍了cGMP调节药物治疗的当前和未来治疗应用（）。

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