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Combined PET/MRI: Global Warming—Summary Report of the 6th International Workshop on PET/MRI March 27–29 2017 Tübingen Germany

机译:PET / MRI结合:全球变暖-第六届PET / MRI国际研讨会摘要报告2017年3月27日至29日德国蒂宾根

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摘要

The 6th annual meeting to address key issues in positron emission tomography (PET)/magnetic resonance imaging (MRI) was held again in Tübingen, Germany, from March 27 to 29, 2017. Over three days of invited plenary lectures, round table discussions and dialogue board deliberations, participants critically assessed the current state of PET/MRI, both clinically and as a research tool, and attempted to chart future directions. The meeting addressed the use of PET/MRI and workflows in oncology, neurosciences, infection, inflammation and chronic pain syndromes, as well as deeper discussions about how best to characterise the tumour microenvironment, optimise the complementary information available from PET and MRI, and how advanced data mining and bioinformatics, as well as information from liquid biomarkers (circulating tumour cells and nucleic acids) and pathology, can be integrated to give a more complete characterisation of disease phenotype. Some issues that have dominated previous meetings, such as the accuracy of MR-based attenuation correction (AC) of the PET scan, were finally put to rest as having been adequately addressed for the majority of clinical situations. Likewise, the ability to standardise PET systems for use in multicentre trials was confirmed, thus removing a perceived barrier to larger clinical imaging trials. The meeting openly questioned whether PET/MRI should, in all cases, be used as a whole-body imaging modality or whether in many circumstances it would best be employed to give an in-depth study of previously identified disease in a single organ or region. The meeting concluded that there is still much work to be done in the integration of data from different fields and in developing a common language for all stakeholders involved. In addition, the participants advocated joint training and education for individuals who engage in routine PET/MRI. It was agreed that PET/MRI can enhance our understanding of normal and disrupted biology, and we are in a position to describe the in vivo nature of disease processes, metabolism, evolution of cancer and the monitoring of response to pharmacological interventions and therapies. As such, PET/MRI is a key to advancing medicine and patient care.
机译:2017年3月27日至29日,在德国图宾根再次举行了第六届年度会议,以解决正电子发射断层扫描(PET)/磁共振成像(MRI)的关键问题。为期三天的受邀全体演讲,圆桌讨论和在对话委员会的讨论中,参与者从临床和研究工具的角度严格评估了PET / MRI的当前状态,并试图绘制未来的方向。会议讨论了在肿瘤学,神经科学,感染,炎症和慢性疼痛综合征中使用PET / MRI和工作流程,以及关于如何最好地表征肿瘤微环境,优化可从PET和MRI获得的补充信息以及如何进行更深入的讨论。可以集成先进的数据挖掘和生物信息学,以及来自液体生物标志物(循环肿瘤细胞和核酸)和病理学的信息,以更全面地表征疾病表型。由于在大多数临床情况中都已得到适当解决,因此以前的会议中占据主导地位的一些问题,例如基于MR的基于MR的衰减校正(AC)的准确性,终于得以解决。同样,证实了将PET系统标准化用于多中心试验的能力,从而消除了对大型临床成像试验的感知障碍。会议公开询问是否在所有情况下都应将PET / MRI用作全身成像方式,或者在许多情况下是否最好将其用于对单个器官或区域中先前发现的疾病进行深入研究。会议的结论是,在整合来自不同领域的数据以及为所有相关利益方开发通用语言方面,仍有许多工作要做。此外,参与者提倡对从事常规PET / MRI的个人进行联合培训和教育。公认的是,PET / MRI可以增强我们对正常和破坏生物学的理解,并且我们能够描述疾病过程的体内性质,新陈代谢,癌症的演变以及对药理学干预和疗法的反应监测。因此,PET / MRI是推进医学和患者护理的关键。

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