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首页> 美国卫生研究院文献>Springer Open Choice >Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep
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Over-the-counter medications containing diphenhydramine and doxylamine used by older adults to improve sleep

机译：老年人使用的包含苯海拉明和多西拉敏的非处方药用于改善睡眠

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Background The unintentional misuse of over-the-counter sleep aids among older adults is an important public health problem and a focus of Healthy People 2020. Accordingly, the 2015 Beers Criteria for Potentially Inappropriate Medication Use in Older Adults recommends that individuals 65 years or older avoid use of diphenhydramine and doxylamine; however, many over-the-counter sleep products contain these active ingredients. Objective To identify the proportion of older adults using an over-the-counter medication containing diphenhydramine or doxylamine, and compare their characteristics with older adults using an over-the-counter medication that does not contain these ingredients. Setting Study participants were recruited from the Community Registry of the Pittsburgh Claude D. Pepper Older Americans Independence Center. Method The study sample was taken from a larger survey of 1025 participants on sleep health and over-the-counter sleep medication use conducted from February to April 2015. A subset of 169 participants aged 65 and older reporting taking at least one over-the-counter product to improve sleep within the past 30 days (16.5%) were selected for our analysis on associations between participant characteristics and potentially inappropriate use of over-the-counter sleep medications. Main outcome measure The proportion and characteristics of older adults taking at least one over-the-counter medication containing diphenhydramine or doxylamine. Results Of the 223 over-the-counter sleep medications listed by participants, 115 (52%) contained diphenhydramine or doxylamine. Using the Beers Criteria, we found that more than half of participants (59%) had used a potentially inappropriate over-the-counter medication containing diphenhydramine or doxylamine to improve sleep within the past 30 days. Participants taking at least one diphenhydramine or doxylamine containing medication were less likely to be aware of any safety risks in taking over-the-counter sleep medications than participants not taking these products (38 vs 49%, p = 0.016). Conclusion A majority of older adults in a limited sample from the United States taking an over-the-counter medication to improve sleep are taking a product containing diphenhydramine or doxylamine, both of which are classified as potentially inappropriate for older adults. Awareness of the safety risks of over-the-counter medications and addressing conditions that impact sleep quality could be facilitated through consultation with pharmacists and other healthcare providers.Electronic supplementary materialThe online version of this article (doi:10.1007/s11096-017-0467-x) contains supplementary material, which is available to authorized users.
机译：背景技术老年人无意间滥用非处方睡眠辅助剂是一个重要的公共卫生问题，也是2020年健康人群的关注重点。因此，2015年《啤酒关于老年人可能不适当用药的准则》建议65岁以上的人避免使用苯海拉明和多西拉敏；但是，许多非处方睡眠产品都含有这些活性成分。目的确定使用含苯海拉明或多西拉敏的非处方药物的老年人的比例，并使用不含这些成分的非处方药物与老年人的特征进行比较。背景研究参与者是从匹兹堡克劳德·D·佩珀尔美国老年人独立中心的社区登记处招募的。方法该研究样本来自2015年2月至2015年4月进行的一项针对1025名参与者的睡眠健康和非处方睡眠药物使用的更大调查。一部分169名65岁及65岁以上的参与者报告至少进行了一次我们选择了过去30天内改善睡眠的柜台产品（16.5％）进行分析参与者特征与可能不适当使用非处方睡眠药物之间的关联。主要结果指标老年人服用至少一种含苯海拉明或多西拉敏的非处方药的比例和特征。结果参与者列出的223种非处方睡眠药物中，有115种（52％）含有苯海拉明或多西拉敏。使用比尔斯准则，我们发现超过一半的参与者（59％）在过去30天内使用了可能不合适的含有苯海拉明或多西拉敏的非处方药来改善睡眠。与不服用这些产品的参与者相比，至少服用一种含苯海拉明或多西拉敏的药物的参与者不太可能意识到服用非处方睡眠药物的任何安全风险（38 vs 49％，p = 0.016）。结论来自美国的有限样本中的大多数老年人正在服用非处方药以改善睡眠，他们正在服用一种含有苯海拉明或多西拉敏的产品，这两种产品均被归类为不适合老年人使用。可以通过与药剂师和其他卫生保健提供者进行协商来提高对非处方药安全风险的认识以及解决影响睡眠质量的状况。电子补充材料本文的在线版本（doi：10.1007 / s11096-017-0467- x）包含补充材料，授权用户可以使用。

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