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Evolutionary algorithms and synthetic biology for directed evolution: commentary on on the mapping of genotype to phenotype in evolutionary algorithms by Peter A. Whigham Grant Dick and James Maclaurin

机译：用于定向进化的进化算法和合成生物学：Peter A. WhighamGrant Dick和James Maclaurin对关于进化算法中基因型到表型的映射的评论

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I rehearse two issues around the commentary of Whigham and colleagues. (1) There really are many more reasons than those given as to why natural evolution cannot reasonably find or select the ‘optimal’ individual. (2) A series of experimental molecular biology programmes, known generically as directed evolution, can use operators and selection schemes that natural evolution cannot. When developed further using the methods of synthetic biology, there are no operators or schemes for in silico evolution that cannot be applied precisely to directed evolution. The issues raised apply only to natural evolution but not to directed evolution.

机译：我将根据Whigham及其同事的评论来演练两个问题。（1）关于自然进化为何无法合理地找到或选择“最优”个体的原因，确实有很多原因。（2）一系列实验性分子生物学程序（通常称为定向进化）可以使用自然进化无法实现的算子和选择方案。当使用合成生物学方法进一步发展时，没有计算机进化的运算符或方案不能精确地应用于定向进化。提出的问题仅适用于自然进化，而不适用于定向进化。

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期刊名称 Springer Open Choice
作者
Douglas B. Kell;
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作者单位

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年(卷),期 -1(18),3
年度 -1
页码 373–378
总页数 6
原文格式 PDF
正文语种
中图分类外科学;
关键词
Directed evolution Synthetic biology Navigating search spaces Intelligent operators;

机译：定向进化;合成生物学;导航搜索空间;智能算子;

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1. Evolutionary algorithms and synthetic biology for directed evolution: commentary on "on the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin [J] . Kell Douglas B. Genetic programming and evolvable machines . 2017,第3期

机译：定向进化的进化算法和合成生物学：Peter A. Whigham，Grant Dick和James Maclaurin评述“关于进化算法中基因型到表型的映射”
2. A rebuttal to Whigham, Dick, and Maclaurin by one of the inventors of Grammatical Evolution: Commentary on "On the Mapping of Genotype to Phenotype in Evolutionary Algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin [J] . Ryan Conor Genetic programming and evolvable machines . 2017,第3期

机译：语法进化的一位发明家对Whigham，Dick和Maclaurin的反驳：彼得A. Whigham，Grant Dick和James Maclaurin对“论进化算法中基因型到表型的映射”的评论
3. Genotype-phenotype mapping implications for genetic programming representation: Commentary on "On the mapping of genotype to phenotype in evolutionary algorithms" by Peter A. Whigham, Grant Dick, and James Maclaurin [J] . Ekart Aniko, Lewis Peter R. Genetic programming and evolvable machines . 2017,第3期

机译：基因型-表型作图对遗传程序表示的影响：Peter A. Whigham，Grant Dick和James Maclaurin对“论进化算法中的基因型到表型作图”的评论
4. Evolvability in Evolutionary Robotics: Evolving the Genotype-Phenotype Mapping [C] . Koenig Lukas, Schmeck Hartmut 4th IEEE International Conference on Self-Adaptive and Self-Organizing Systems . 2010

机译：进化机器人中的可进化性：基因型-表型作图的发展
5. Mapping to coarse grain reconfigurable arrays using evolutionary algorithms. [D] . Ma, Fred (Shing-Fat). 2005

机译：使用进化算法映射到粗粮可重构阵列。
6. Evolutionary Connectionism: Algorithmic Principles Underlying the Evolution of Biological Organisation in Evo-Devo Evo-Eco and Evolutionary Transitions [O] . Richard A. Watson, Rob Mills, C. L. Buckley, -1

机译：进化联系主义：Evo-DevoEvo-Eco和进化转变中生物组织进化背后的算法原理
7. Evolutionary algorithms and synthetic biology for directed evolution: commentary on “on the mapping of genotype to phenotype in evolutionary algorithms” by Peter A. Whigham, Grant Dick, and James Maclaurin [O] . 2017

机译：用于定向进化的进化算法和合成生物学：Peter A. Whigham，Grant Dick和James Maclaurin对“关于进化算法中基因型到表型的映射”的评论

Evolutionary algorithms and synthetic biology for directed evolution: commentary on on the mapping of genotype to phenotype in evolutionary algorithms by Peter A. Whigham Grant Dick and James Maclaurin

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